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dc.contributor.authorWang, Jingen_US
dc.contributor.authorLindholt, Jes Sen_US
dc.contributor.authorSukhova, Galina Ken_US
dc.contributor.authorShi, Michael Aen_US
dc.contributor.authorXia, Mingcanen_US
dc.contributor.authorChen, Hanen_US
dc.contributor.authorXiang, Meixiangen_US
dc.contributor.authorHe, Ainaen_US
dc.contributor.authorWang, Yien_US
dc.contributor.authorXiong, Naen_US
dc.contributor.authorLibby, Peteren_US
dc.contributor.authorWang, Jian-Anen_US
dc.contributor.authorShi, Guo-Pingen_US
dc.date.accessioned2014-09-08T15:37:41Z
dc.date.issued2014en_US
dc.identifier.citationWang, J., J. S. Lindholt, G. K. Sukhova, M. A. Shi, M. Xia, H. Chen, M. Xiang, et al. 2014. “IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.” EMBO Molecular Medicine 6 (7): 952-969. doi:10.15252/emmm.201303811. http://dx.doi.org/10.15252/emmm.201303811.en
dc.identifier.issn1757-4676en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785965
dc.description.abstractImmunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates that CD4+ T cells express IgE receptor FcεR1, at much higher levels than do CD8+ T cells. IgE induces CD4+ T-cell production of IL6 and IFN-γ, but reduces their production of IL10. FcεR1 deficiency (Fcer1a−/−) protects apolipoprotein E-deficient (Apoe−/−) mice from angiotensin-II infusion-induced AAAs and reduces plasma IL6 levels. Adoptive transfer of CD4+ T cells (but not CD8+ T cells), MCs, and macrophages from Apoe−/− mice, but not those from Apoe−/− Fcer1a−/− mice, increases AAA size and plasma IL6 in Apoe−/− Fcer1a−/− recipient mice. Biweekly intravenous administration of an anti-IgE monoclonal antibody ablated plasma IgE and reduced AAAs in Apoe−/− mice. Patients with AAAs had significantly higher plasma IgE levels than those without AAAs. This study establishes an important role of IgE in AAA pathogenesis by activating CD4+ T cells, MCs, and macrophages and supports consideration of neutralizing plasma IgE in the therapeutics of human AAAs.en
dc.language.isoen_USen
dc.publisherBlackWell Publishing Ltden
dc.relation.isversionofdoi:10.15252/emmm.201303811en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119357/pdf/en
dash.licenseLAAen_US
dc.subjectabdominal aortic aneurysmen
dc.subjectIgEen
dc.subjectmacrophageen
dc.subjectmast cellen
dc.subjectT cellsen
dc.titleIgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysmsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEMBO Molecular Medicineen
dash.depositing.authorWang, Jingen_US
dc.date.available2014-09-08T15:37:41Z
dc.identifier.doi10.15252/emmm.201303811*
dash.authorsorderedfalse
dash.contributor.affiliatedWang, Jing
dash.contributor.affiliatedSukhova, Galina
dash.contributor.affiliatedChen, Han
dash.contributor.affiliatedShi, Guo-Ping
dash.contributor.affiliatedLibby, Peter
dc.identifier.orcid0000-0002-1502-502X


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