A cortical-spinal prosthesis for targeted limb movement in paralyzed primate avatars
Shanechi, Maryam M.
Hu, Rollin C.
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CitationShanechi, Maryam M., Rollin C. Hu, and Ziv M. Williams. 2014. “A cortical-spinal prosthesis for targeted limb movement in paralyzed primate avatars.” Nature communications 5 (1): 3237. doi:10.1038/ncomms4237. http://dx.doi.org/10.1038/ncomms4237.
AbstractMotor paralysis is among the most disabling aspects of injury to the central nervous system. Here we develop and test a target-based cortical-spinal neural prosthesis that employs neural activity recorded from pre-motor neurons to control limb movements in functionally paralyzed primate avatars. Given the complexity by which muscle contractions are naturally controlled, we approach the problem of eliciting goal-directed limb movement in paralyzed animals by focusing on the intended targets of movement rather than their intermediate trajectories. We then match this information in real-time with spinal cord and muscle stimulation parameters that produce free planar limb movements to those intended target locations. We demonstrate that both the decoded activities of pre-motor populations and their adaptive responses can be used, after brief training, to effectively direct an avatar’s limb to distinct targets variably displayed on a screen. These findings advance the future possibility of reconstituting targeted limb movement in paralyzed subjects.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785969
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