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dc.contributor.authorLiu, Suen_US
dc.contributor.authorChen, Zhenyuen_US
dc.contributor.authorCai, Xiaen_US
dc.contributor.authorSun, Yingen_US
dc.contributor.authorZhao, Cailingen_US
dc.contributor.authorLiu, Fangjunen_US
dc.contributor.authorLiu, Dalieen_US
dc.date.accessioned2014-09-08T15:37:50Z
dc.date.issued2014en_US
dc.identifier.citationLiu, Su, Zhenyu Chen, Xia Cai, Ying Sun, Cailing Zhao, Fangjun Liu, and Dalie Liu. 2014. “Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat.” The Scientific World Journal 2014 (1): 507351. doi:10.1155/2014/507351. http://dx.doi.org/10.1155/2014/507351.en
dc.identifier.issn2356-6140en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785982
dc.description.abstractA lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0.1% DMAE + AA and 0.2% DMAE + AA groups appeared significantly thicker than aging control rats. No differences were found in tissue water content among groups. Hydroxyproline in 0.1% DMAE + AA, 0.2% DMAE + AA, and sham control groups was much higher than all other groups. Collagen type I, type III, and MMP-1 expression was highly upregulated in both 0.1% DMAE + AA and 0.2% DMAE + AA groups compared with aging control. In contrast, TIMP-1 expression levels of various aging groups were significantly reduced when compared to sham control. Coinjection of DMAE and AA into target tissue has marked antiaging effects on D-galactose induced skin aging model of rat.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2014/507351en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123624/pdf/en
dash.licenseLAAen_US
dc.titleEffects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Raten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalThe Scientific World Journalen
dc.date.available2014-09-08T15:37:50Z
dc.identifier.doi10.1155/2014/507351*
dash.authorsorderedfalse


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