Sorting Out a Promiscuous Superfamily: Towards Cadherin Connectomics

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Sorting Out a Promiscuous Superfamily: Towards Cadherin Connectomics

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Title: Sorting Out a Promiscuous Superfamily: Towards Cadherin Connectomics
Author: Sotomayor, Marcos; Gaudet, Rachelle; Corey, David Paul

Note: Order does not necessarily reflect citation order of authors.

Citation: Sotomayor, Marcos, Rachelle Gaudet, and David P. Corey. 2014. Sorting Out a Promiscuous Superfamily: Towards Cadherin Connectomics. Trends in Cell Biology 24, no. 9: 524–536.
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Abstract: Members of the cadherin superfamily of proteins are involved in diverse biological processes such as morphogenesis, sound transduction, and neuronal connectivity. Key to cadherin function is their extracellular domain containing cadherin repeats, which can mediate interactions involved in adhesion and cell signaling. Recent cellular, biochemical, and structural studies have revealed that physical interaction among cadherins is more complex than originally thought. Here we review work on new cadherin complexes and discuss how the classification of the mammalian family can be used to search for additional cadherin-interacting partners. We also highlight some of the challenges in cadherin research; namely, the characterization of a cadherin connectome in biochemical and structural terms, as well as the elucidation of molecular mechanisms underlying the functional diversity of nonclassical cadherins in vivo.
Published Version: doi:10.1016/j.tcb.2014.03.007
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12872205
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