Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort

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Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort

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dc.contributor.author Puett, Robin C. en_US
dc.contributor.author Hart, Jaime E. en_US
dc.contributor.author Yanosky, Jeff D. en_US
dc.contributor.author Spiegelman, Donna en_US
dc.contributor.author Wang, Molin en_US
dc.contributor.author Fisher, Jared A. en_US
dc.contributor.author Hong, Biling en_US
dc.contributor.author Laden, Francine en_US
dc.date.accessioned 2014-10-01T14:27:47Z
dc.date.issued 2014 en_US
dc.identifier.citation Puett, Robin C., Jaime E. Hart, Jeff D. Yanosky, Donna Spiegelman, Molin Wang, Jared A. Fisher, Biling Hong, and Francine Laden. 2014. “Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort.” Environmental Health Perspectives 122 (9): 926-932. doi:10.1289/ehp.1307490. http://dx.doi.org/10.1289/ehp.1307490. en
dc.identifier.issn 0091-6765 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987238
dc.description.abstract Background: A body of literature has suggested an elevated risk of lung cancer associated with particulate matter and traffic-related pollutants. Objective: We examined the relation of lung cancer incidence with long-term residential exposures to ambient particulate matter and residential distance to roadway, as a proxy for traffic-related exposures. Methods: For participants in the Nurses’ Health Study, a nationwide prospective cohort of women, we estimated 72-month average exposures to PM2.5, PM2.5–10, and PM10 and residential distance to road. Follow-up for incident cases of lung cancer occurred from 1994 through 2010. Cox proportional hazards models were adjusted for potential confounders. Effect modification by smoking status was examined. Results: During 1,510,027 person-years, 2,155 incident cases of lung cancer were observed among 103,650 participants. In fully adjusted models, a 10-μg/m3 increase in 72-month average PM10 [hazard ratio (HR) = 1.04; 95% CI: 0.95, 1.14], PM2.5 (HR = 1.06; 95% CI: 0.91, 1.25), or PM2.5–10 (HR = 1.05; 95% CI: 0.92, 1.20) was positively associated with lung cancer. When the cohort was restricted to never-smokers and to former smokers who had quit at least 10 years before, the associations appeared to increase and were strongest for PM2.5 (PM10: HR = 1.15; 95% CI: 1.00, 1.32; PM2.5: HR = 1.37; 95% CI: 1.06, 1.77; PM2.5–10: HR = 1.11; 95% CI: 0.90, 1.37). Results were most elevated when restricted to the most prevalent subtype, adenocarcinomas. Risks with roadway proximity were less consistent. Conclusions: Our findings support those from other studies indicating increased risk of incident lung cancer associated with ambient PM exposures, especially among never- and long-term former smokers. Citation: Puett RC, Hart JE, Yanosky JD, Spiegelman D, Wang M, Fisher JA, Hong B, Laden F. 2014. Particulate matter air pollution exposure, distance to road, and incident lung cancer in the Nurses’ Health Study Cohort. Environ Health Perspect 122:926–932; http://dx.doi.org/10.1289/ehp.1307490 en
dc.language.iso en_US en
dc.publisher NLM-Export en
dc.relation.isversionof doi:10.1289/ehp.1307490 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154215/pdf/ en
dash.license LAA en_US
dc.title Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Environmental Health Perspectives en
dash.depositing.author Hart, Jaime E. en_US
dc.date.available 2014-10-01T14:27:47Z

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