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dc.contributor.authorMehta, Amar J.en_US
dc.contributor.authorKloog, Itaien_US
dc.contributor.authorZanobetti, Antonellaen_US
dc.contributor.authorCoull, Brent A.en_US
dc.contributor.authorSparrow, Daviden_US
dc.contributor.authorVokonas, Pantelen_US
dc.contributor.authorSchwartz, Joelen_US
dc.date.accessioned2014-10-01T14:27:54Z
dc.date.issued2014en_US
dc.identifier.citationMehta, Amar J., Itai Kloog, Antonella Zanobetti, Brent A. Coull, David Sparrow, Pantel Vokonas, and Joel Schwartz. 2014. “Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study.” PLoS ONE 9 (9): e106258. doi:10.1371/journal.pone.0106258. http://dx.doi.org/10.1371/journal.pone.0106258.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12987252
dc.description.abstractBackground: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men. Methods: This longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three visits between 2000–2008 (n = 743). We analyzed associations between QTc and moving averages (1–7, 14, 21, and 28 days) of the 24-hour mean and standard deviation of temperature as measured from a local weather monitor, and the 24-hour mean temperature estimated from a spatiotemporal prediction model, in time-varying linear mixed-effect regression. Effect modification by season, diabetes, coronary heart disease, obesity, and age was also evaluated. Results: Higher mean temperature as measured from the local monitor, and estimated from the prediction model, was associated with longer QTc at moving averages of 21 and 28 days. Increased 24-hr standard deviation of temperature was associated with longer QTc at moving averages from 4 and up to 28 days; a 1.9°C interquartile range increase in 4-day moving average standard deviation of temperature was associated with a 2.8 msec (95%CI: 0.4, 5.2) longer QTc. Associations between 24-hr standard deviation of temperature and QTc were stronger in colder months, and in participants with diabetes and coronary heart disease. Conclusion/Significance In this sample of older men, elevated mean temperature was associated with longer QTc, and increased variability of temperature was associated with longer QTc, particularly during colder months and among individuals with diabetes and coronary heart disease. These findings may offer insight of an important underlying mechanism of temperature-related cardiovascular morbidity and mortality in an older population.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0106258en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169528/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectObesityen
dc.subjectElectrophysiologyen
dc.subjectGeneticsen
dc.subjectHuman Geneticsen
dc.subjectNutritionen
dc.subjectPopulation Biologyen
dc.subjectEarth Sciencesen
dc.subjectAtmospheric Scienceen
dc.subjectMeteorologyen
dc.subjectClinical Research Designen
dc.subjectCohort Studiesen
dc.subjectMedicine and Health Sciencesen
dc.subjectHealth Careen
dc.subjectEnvironmental Healthen
dc.subjectCardiologyen
dc.subjectCardiovascular Diseasesen
dc.subjectArrhythmiaen
dc.subjectGeriatric Cardiologyen
dc.subjectClinical Geneticsen
dc.subjectMitochondrial Diseasesen
dc.subjectDiabetes Mellitus and Deafnessen
dc.subjectEpidemiologyen
dc.subjectCardiovascular Disease Epidemiologyen
dc.subjectEnvironmental Epidemiologyen
dc.subjectVascular Medicineen
dc.subjectCoronary Artery Diseaseen
dc.subjectGeriatricsen
dc.subjectPublic and Occupational Healthen
dc.titleAssociations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorMehta, Amar J.en_US
dc.date.available2014-10-01T14:27:54Z
dc.identifier.doi10.1371/journal.pone.0106258*
dash.contributor.affiliatedSparrow, David
dash.contributor.affiliatedMehta, A
dash.contributor.affiliatedZanobetti, Antonella
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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