Prevalence and Correlates of Diabetic Peripheral Neuropathy in a Saudi Arabic Population: A Cross-Sectional Study

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Prevalence and Correlates of Diabetic Peripheral Neuropathy in a Saudi Arabic Population: A Cross-Sectional Study

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dc.contributor.author Wang, Dong D. en_US
dc.contributor.author Bakhotmah, Balkees A. en_US
dc.contributor.author Hu, Frank B. en_US
dc.contributor.author Alzahrani, Hasan Ali en_US
dc.date.accessioned 2014-10-01T14:27:58Z
dc.date.issued 2014 en_US
dc.identifier.citation Wang, Dong D., Balkees A. Bakhotmah, Frank B. Hu, and Hasan Ali Alzahrani. 2014. “Prevalence and Correlates of Diabetic Peripheral Neuropathy in a Saudi Arabic Population: A Cross-Sectional Study.” PLoS ONE 9 (9): e106935. doi:10.1371/journal.pone.0106935. http://dx.doi.org/10.1371/journal.pone.0106935. en
dc.identifier.issn 1932-6203 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987260
dc.description.abstract The purpose of this cross-sectional study was to investigate the prevalence and correlates of diabetic peripheral neuropathy (DPN) in a Saudi population. The study population consisted of 552 diabetic participants with an average age of 53.4 years. Among this population, 62.7% were male and 94.9% had type 2 diabetes. The average body mass index was 31.1 kg/m2. DPN was diagnosed based on a combination of reduced vibration perception measured by neurothesiometer and/or reduced light touch perception evaluated by the 10-g Semmes-Weinstein monofilament, as well as neurological symptoms. Information on socio-demographic variables, smoking status, duration of diabetes, and medications was obtained through interviews by physicians. Body weight, height, waist circumference, blood pressure and clinical markers were assessed following standard procedures. The prevalence of DPN in this population was 19.9% (95% CI, 16.7%-23.5%). In the multivariable analyses, longer duration of diabetes [odds ratio (OR) for every 5-year increase, 2.49, 95% CI, 1.75-3.53], abdominal obesity (OR, 2.53, 95% CI, 1.41-4.55), and higher levels of fasting blood glucose (OR for every 1 mmol/L increase, 1.05, 95% CI, 0.99-1.12), creatinine (OR for every 10 µmol/L increase, 1.07, 95% CI, 0.99-1.14) and white blood cell count (OR for every 106/L increase, 1.08, 95% CI, 1.01-1.16) were associated with higher odds of DPN, while oral hypoglycemic medication use was associated with a lower odds of DPN (OR, 0.47, 95% CI, 0.26-0.85). In this large Saudi population, several correlates for DPN, in addition to glycemic control and diabetes duration, were identified, including abdominal obesity, creatinine and white blood cell count. en
dc.language.iso en_US en
dc.publisher Public Library of Science en
dc.relation.isversionof doi:10.1371/journal.pone.0106935 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153691/pdf/ en
dash.license LAA en_US
dc.subject Biology and Life Sciences en
dc.subject Anatomy en
dc.subject Nervous System en
dc.subject Nutrition en
dc.subject Physiology en
dc.subject Physiological Parameters en
dc.subject Body Weight en
dc.subject Obesity en
dc.subject Medicine and Health Sciences en
dc.subject Cardiology en
dc.subject Endocrinology en
dc.subject Diabetic Endocrinology en
dc.subject Epidemiology en
dc.subject Biomarker Epidemiology en
dc.subject Cardiovascular Disease Epidemiology en
dc.subject Metabolic Disorders en
dc.subject Diabetes Mellitus en
dc.subject Type 1 Diabetes en
dc.subject Type 2 Diabetes en
dc.subject Neurology en
dc.subject Neuromuscular Diseases en
dc.subject Public and Occupational Health en
dc.subject Global Health en
dc.subject Vascular Medicine en
dc.subject Vascular Diseases en
dc.subject Peripheral Vascular Disease en
dc.title Prevalence and Correlates of Diabetic Peripheral Neuropathy in a Saudi Arabic Population: A Cross-Sectional Study en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal PLoS ONE en
dash.depositing.author Hu, Frank B. en_US
dc.date.available 2014-10-01T14:27:58Z

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