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dc.contributor.authorVan Epps, Pujaen_US
dc.contributor.authorMatining, Roy M.en_US
dc.contributor.authorTassiopoulos, Katherineen_US
dc.contributor.authorAnthony, Donald D.en_US
dc.contributor.authorLanday, Alanen_US
dc.contributor.authorKalayjian, Robert C.en_US
dc.contributor.authorCanaday, David H.en_US
dc.date.accessioned2014-10-01T14:28:05Z
dc.date.issued2014en_US
dc.identifier.citationVan Epps, Puja, Roy M. Matining, Katherine Tassiopoulos, Donald D. Anthony, Alan Landay, Robert C. Kalayjian, and David H. Canaday. 2014. “Older Age Is Associated with Peripheral Blood Expansion of Naïve B Cells in HIV-Infected Subjects on Antiretroviral Therapy.” PLoS ONE 9 (9): e107064. doi:10.1371/journal.pone.0107064. http://dx.doi.org/10.1371/journal.pone.0107064.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12987267
dc.description.abstractOlder HIV infected subjects were previously found to have significant B cell expansion during initial antiretroviral therapy in a prospective age-differentiated cohort of older and younger (≥45 vs. ≤30 years) HIV-infected subjects initiating antiretroviral therapy (ART) through the AIDS Clinical Trials Group. Here to further describe this expansion, using a subset of subjects from the same cohort, we characterized B cell phenotypes at baseline and after 192 weeks of ART in both older and younger HIV-infected groups and compared them to uninfected age-matched controls. We also examined whether phenotypes at baseline associated with response to tetanus and hepatitis A vaccine at 12 weeks. Forty six subjects were analyzed in the HIV infected group (21 older, 25 younger) and 30 in the control group (15 per age group). We observed naïve B cells to normalize in younger subjects after 192 weeks of ART, while in older subjects naïve B cells increased to greater levels than those of controls (p = 0.045). Absolute resting memory (RM) cell count was significantly lower in the older HIV infected group at baseline compared to controls and numbers normalized after 192 weeks of ART (p<0.001). Baseline RM cell count positively correlated with week 12 increase in antibody to tetanus vaccine among both younger and older HIV-infected subjects combined (p = 0.01), but not in controls. The age-associated naïve B cell expansion is a novel finding and we discuss several possible explanations for this observation. Relationship between RM cells at baseline and tetanus responses may lead to insights about the effects of HIV infection on B cell memory function and vaccine responses.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0107064en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160206/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and health sciencesen
dc.subjectInfectious diseasesen
dc.subjectViral diseasesen
dc.subjectAIDSen
dc.subjectHIV infectionsen
dc.titleOlder Age Is Associated with Peripheral Blood Expansion of Naïve B Cells in HIV-Infected Subjects on Antiretroviral Therapyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dc.date.available2014-10-01T14:28:05Z
dc.identifier.doi10.1371/journal.pone.0107064*


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