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dc.contributor.authorEssex, M.en_US
dc.date.accessioned2014-10-01T14:28:09Z
dc.date.issued2014en_US
dc.identifier.citationEssex, M. 2014. “140 Reversing the Epidemic of HIV-1C in Southern Africa with Treatment as Prevention.” Journal of Acquired Immune Deficiency Syndromes (1999) 65 (Suppl 2): 59. doi:10.1097/01.qai.0000446720.60423.1e. http://dx.doi.org/10.1097/01.qai.0000446720.60423.1e.en
dc.identifier.issn1525-4135en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12987279
dc.description.abstractThe epidemic of HIV-1C in southern Africa is characterized by a sustained prevalence that is substantially higher than for other epidemics of HIV/AIDS. Perhaps the best correlate of transmission is high viral load (HVL), which we target to prevent spread of HIV in a community randomization trial based on antiretroviral treatment (ART) as prevention (TasP). Designed for over 100,000 adults in 30 randomized villages in Botswana, this trial also utilizes other prevention interventions such as HIV testing, male circumcision, clinical linkage and ART chemoprophylaxis during pregnancy. Viral phylogenetics is used to estimate the proportion of incident infections originating in test villages, and thus the relative contribution of TasP for preventing transmissions. Analysis of results through modeling includes estimating cost effectiveness and estimations of contributions for different prevention interventions.en
dc.language.isoen_USen
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen
dc.relation.isversionofdoi:10.1097/01.qai.0000446720.60423.1een
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149622/pdf/en
dash.licenseLAAen_US
dc.subjectAbstracts—September 10, 2013 (Day 3)en
dc.title140 Reversing the Epidemic of HIV-1C in Southern Africa with Treatment as Preventionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of Acquired Immune Deficiency Syndromes (1999)en
dc.date.available2014-10-01T14:28:09Z
dc.identifier.doi10.1097/01.qai.0000446720.60423.1e*


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