dc.contributor.author | Beydoun, May A. | en_US |
dc.contributor.author | Tanaka, Toshiko | en_US |
dc.contributor.author | Beydoun, Hind A. | en_US |
dc.contributor.author | Ding, Eric L. | en_US |
dc.contributor.author | Ferrucci, Luigi | en_US |
dc.contributor.author | Zonderman, Alan B. | en_US |
dc.date.accessioned | 2014-10-01T14:28:10Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Beydoun, May A., Toshiko Tanaka, Hind A. Beydoun, Eric L. Ding, Luigi Ferrucci, and Alan B. Zonderman. 2013. “Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults.” Journal of Nutritional Science 2 (1): e33. doi:10.1017/jns.2013.19. http://dx.doi.org/10.1017/jns.2013.19. | en |
dc.identifier.issn | 2048-6790 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987282 | |
dc.description.abstract | We examined longitudinal associations of vitamin D receptor (VDR) and megalin (LRP2; LDL receptor-related protein-2) gene polymorphisms with central adiposity. We used data from the Baltimore Longitudinal Study of Aging (BLSA), an ongoing prospective open cohort study. Study participants consisted of non-Hispanic white adults residing in Baltimore city, with one or more visits at age ≥50 years, and complete data (n 609–617). Repeated assessments on waist circumference (WC) and waist:hip ratio (WHR) were available. Multiple linear mixed models were used to estimate mid-follow-up age central adiposity level and annual rate of change with cut-points set at the sex-specific 80th percentile. The four binary outcomes were: ‘elevated central adiposity’ (ECA-WC and ECA-WHR) and ‘significant increase in central adiposity’ (SICA-WC and SICA-WHR). SNP for VDR (four SNP: (1) rs11568820 (CdX-2:T/C); (2) rs1544410 (BsmI:G/A); (3) rs7975232 (ApaI:A/C); (4) rs731236 (TaqI:G/A)) and Megalin (three SNP: (1) rs3755166:G/A; (2) rs2075252:C/T; (3) rs4668123:C/T) genes were selected. SNP latent classes (SNPLC) and SNP haplotypes (SNPHAP) were created. Multiple logistic regression analyses indicated that, in men, higher ECA-WHR odds were associated with SNPLC Megalin2:rs3755166[–]/rs2075252[TT]/rs4668123[T–] (v. Megalin1:rs3755166[–]/rs2075252[CC]/rs4668123[–]) (OR 2·87; 95 % CI 1·15, 7·12; P = 0·023) and that SNPLC Megalin3:rs3755166[–]/rs2075252[CT]/rs4668123[–] (v. Megalin1) was linked to lower SICA-WC odds (OR 0·48; 95 % CI 0·26, 0·88; P = 0·019) (P > 0·05 for sex × SNPLC). In women, VDR3 SNPHAP (GAA:bAT) was related to lower odds of ECA-WC (OR 0·37; 95 % CI 0·16, 0·87; P = 0·023) (P < 0·05 for sex × SNPHAP), VDR1 SNPHAP (GCA:baT) was associated with greater odds and VDR3 SNPHAP (GAA:bAT) with lower odds of SICA-WC (P > 0·05 for sex × SNPHAP). Vitamin D-related gene polymorphisms were associated with central adiposity status and change. Future mechanistic studies are needed to confirm those polymorphisms' biological significance to central adiposity. | en |
dc.language.iso | en_US | en |
dc.publisher | Cambridge University Press | en |
dc.relation.isversionof | doi:10.1017/jns.2013.19 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153078/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Central adiposity | en |
dc.subject | SNP | en |
dc.subject | Vitamin D receptor | en |
dc.subject | Megalin | en |
dc.subject | Adults | en |
dc.subject | BLSA, Baltimore Longitudinal Study of
Aging | en |
dc.subject | ECA, elevated central adiposity | en |
dc.subject | LCA, latent class analysis | en |
dc.subject | LD, linkage disequilibrium | en |
dc.subject | SICA, significant increase in central
adiposity | en |
dc.subject | SNPHAP, SNP halotype | en |
dc.subject | SNPLC, SNP latent class | en |
dc.subject | VDR, vitamin D receptor | en |
dc.subject | WC, waist circumference | en |
dc.subject | WHR, waist:hip ratio | en |
dc.title | Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Journal of Nutritional Science | en |
dash.depositing.author | Ding, Eric L. | en_US |
dc.date.available | 2014-10-01T14:28:10Z | |
dc.identifier.doi | 10.1017/jns.2013.19 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Ding, Eric L. | |