Quantifying the Reconfiguration of Intrinsic Networks during Working Memory

DSpace/Manakin Repository

Quantifying the Reconfiguration of Intrinsic Networks during Working Memory

Citable link to this page

 

 
Title: Quantifying the Reconfiguration of Intrinsic Networks during Working Memory
Author: Cohen, Jessica R.; Gallen, Courtney L.; Jacobs, Emily G.; Lee, Taraz G.; D'Esposito, Mark

Note: Order does not necessarily reflect citation order of authors.

Citation: Cohen, Jessica R., Courtney L. Gallen, Emily G. Jacobs, Taraz G. Lee, and Mark D'Esposito. 2014. “Quantifying the Reconfiguration of Intrinsic Networks during Working Memory.” PLoS ONE 9 (9): e106636. doi:10.1371/journal.pone.0106636. http://dx.doi.org/10.1371/journal.pone.0106636.
Full Text & Related Files:
Abstract: Rapid, flexible reconfiguration of connections across brain regions is thought to underlie successful cognitive control. Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are thought to underlie two operations critical for cognitive control: task-set maintenance/tonic alertness and adaptive, trial-by-trial updating. Using functional magnetic resonance imaging, we directly tested whether the functional connectivity of the CO and FP networks was related to cognitive demands and behavior. We focused on working memory because of evidence that during working memory tasks the entire brain becomes more integrated. When specifically probing the CO and FP cognitive control networks, we found that individual regions of both intrinsic networks were active during working memory and, as expected, integration across the two networks increased during task blocks that required cognitive control. Crucially, increased integration between each of the cognitive control networks and a task-related, non-cognitive control network (the hand somatosensory-motor network; SM) was related to increased accuracy. This implies that dynamic reconfiguration of the CO and FP networks so as to increase their inter-network communication underlies successful working memory.
Published Version: doi:10.1371/journal.pone.0106636
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156328/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987305
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters