Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent

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Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent

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Title: Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent
Author: Overstreet, Michael G.; Gaylo, Alison; Angermann, Bastian; Hughson, Angela; Hyun, Young-min; Lambert, Kris; Acharya, Mridu; Billroth-Maclurg, Alison C.; Rosenberg, Alexander F.; Topham, David J.; Yagita, Hideo; Kim, Minsoo; Lacy-Hulbert, Adam; Meier-Schellersheim, Martin; Fowell, Deborah J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Overstreet, M. G., A. Gaylo, B. Angermann, A. Hughson, Y. Hyun, K. Lambert, M. Acharya, et al. 2014. “Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent.” Nature immunology 14 (9): 949-958. doi:10.1038/ni.2682. http://dx.doi.org/10.1038/ni.2682.
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Abstract: Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues appears to be integrin-independent actin-myosin based, during inflammation changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that T cell interstitial motility was critically dependent on RGD-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to increased αv integrin expression on effector CD4+ T cells. Using intravital multi-photon imaging, we found that CD4+ T cell motility was dependent on αv expression. Selective αv blockade or knockdown arrested TH1 motility in the inflamed tissue and attenuated local effector function. These data show a context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.
Published Version: doi:10.1038/ni.2682
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159184/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987318
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