Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells

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Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells

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Title: Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells
Author: Jeong, Jee-Yeong; Zhou, Jin-Rong; Gao, Chong; Feldman, Laurie; Sytkowski, Arthur J.

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Citation: Jeong, Jee-Yeong, Jin-Rong Zhou, Chong Gao, Laurie Feldman, and Arthur J. Sytkowski. 2014. “Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells.” BMB Reports 47 (7): 411-416. doi:10.5483/BMBRep.2014.47.7.104. http://dx.doi.org/10.5483/BMBRep.2014.47.7.104.
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Abstract: In the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express hSP56 results in a marked inhibition of cell growth in vitro and in vivo. Down-regulation of hSP56 in LNCaP cells that normally express hSP56 results in enhanced anchorage-independent growth. PC-3 cells expressing hSP56 exhibit a significant reduction of hypoxia inducible protein (HIF)-1α protein levels under hypoxic conditions without altering HIF-1α mRNA (HIF1A) levels. Taken together, our findings strongly suggest that hSP56 plays a critical role in prostate cells by mechanisms including negative regulation of HIF-1α, thus identifying hSP56 as a candidate anti-oncogene product. [BMB Reports 2014; 47(7): 411-416]
Published Version: doi:10.5483/BMBRep.2014.47.7.104
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163856/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987331
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