dc.contributor.author | Jeong, Jee-Yeong | en_US |
dc.contributor.author | Zhou, Jin-Rong | en_US |
dc.contributor.author | Gao, Chong | en_US |
dc.contributor.author | Feldman, Laurie | en_US |
dc.contributor.author | Sytkowski, Arthur J. | en_US |
dc.date.accessioned | 2014-10-01T14:28:54Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Jeong, Jee-Yeong, Jin-Rong Zhou, Chong Gao, Laurie Feldman, and Arthur J. Sytkowski. 2014. “Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells.” BMB Reports 47 (7): 411-416. doi:10.5483/BMBRep.2014.47.7.104. http://dx.doi.org/10.5483/BMBRep.2014.47.7.104. | en |
dc.identifier.issn | 1976-6696 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987331 | |
dc.description.abstract | In the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express hSP56 results in a marked inhibition of cell growth in vitro and in vivo. Down-regulation of hSP56 in LNCaP cells that normally express hSP56 results in enhanced anchorage-independent growth. PC-3 cells expressing hSP56 exhibit a significant reduction of hypoxia inducible protein (HIF)-1α protein levels under hypoxic conditions without altering HIF-1α mRNA (HIF1A) levels. Taken together, our findings strongly suggest that hSP56 plays a critical role in prostate cells by mechanisms including negative regulation of HIF-1α, thus identifying hSP56 as a candidate anti-oncogene product. [BMB Reports 2014; 47(7): 411-416] | en |
dc.language.iso | en_US | en |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | en |
dc.relation.isversionof | doi:10.5483/BMBRep.2014.47.7.104 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163856/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Hypoxia inducible factor | en |
dc.subject | Prostate cancer | en |
dc.subject | Protein-protein interaction | en |
dc.subject | pVHL-interacting deubiquitinating enzyme | en |
dc.subject | Selenium binding protein | en |
dc.title | Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | BMB Reports | en |
dash.depositing.author | Zhou, Jin-Rong | en_US |
dc.date.available | 2014-10-01T14:28:54Z | |
dc.identifier.doi | 10.5483/BMBRep.2014.47.7.104 | * |
dash.contributor.affiliated | Zhou, Jin-Rong | |
dash.contributor.affiliated | Gao, Chong | |