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dc.contributor.authorJeong, Jee-Yeongen_US
dc.contributor.authorZhou, Jin-Rongen_US
dc.contributor.authorGao, Chongen_US
dc.contributor.authorFeldman, Laurieen_US
dc.contributor.authorSytkowski, Arthur J.en_US
dc.date.accessioned2014-10-01T14:28:54Z
dc.date.issued2014en_US
dc.identifier.citationJeong, Jee-Yeong, Jin-Rong Zhou, Chong Gao, Laurie Feldman, and Arthur J. Sytkowski. 2014. “Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells.” BMB Reports 47 (7): 411-416. doi:10.5483/BMBRep.2014.47.7.104. http://dx.doi.org/10.5483/BMBRep.2014.47.7.104.en
dc.identifier.issn1976-6696en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12987331
dc.description.abstractIn the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express hSP56 results in a marked inhibition of cell growth in vitro and in vivo. Down-regulation of hSP56 in LNCaP cells that normally express hSP56 results in enhanced anchorage-independent growth. PC-3 cells expressing hSP56 exhibit a significant reduction of hypoxia inducible protein (HIF)-1α protein levels under hypoxic conditions without altering HIF-1α mRNA (HIF1A) levels. Taken together, our findings strongly suggest that hSP56 plays a critical role in prostate cells by mechanisms including negative regulation of HIF-1α, thus identifying hSP56 as a candidate anti-oncogene product. [BMB Reports 2014; 47(7): 411-416]en
dc.language.isoen_USen
dc.publisherKorean Society for Biochemistry and Molecular Biologyen
dc.relation.isversionofdoi:10.5483/BMBRep.2014.47.7.104en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163856/pdf/en
dash.licenseLAAen_US
dc.subjectHypoxia inducible factoren
dc.subjectProstate canceren
dc.subjectProtein-protein interactionen
dc.subjectpVHL-interacting deubiquitinating enzymeen
dc.subjectSelenium binding proteinen
dc.titleHuman selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cellsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMB Reportsen
dash.depositing.authorZhou, Jin-Rongen_US
dc.date.available2014-10-01T14:28:54Z
dc.identifier.doi10.5483/BMBRep.2014.47.7.104*
dash.contributor.affiliatedZhou, Jin-Rong
dash.contributor.affiliatedGao, Chong


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