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dc.contributor.authorBass, Adam J.en_US
dc.contributor.authorThorsson, Vesteinnen_US
dc.contributor.authorShmulevich, Ilyaen_US
dc.contributor.authorReynolds, Sheila M.en_US
dc.contributor.authorMiller, Michaelen_US
dc.contributor.authorBernard, Bradyen_US
dc.contributor.authorHinoue, Toshinorien_US
dc.contributor.authorLaird, Peter W.en_US
dc.contributor.authorCurtis, Christinaen_US
dc.contributor.authorShen, Huien_US
dc.contributor.authorWeisenberger, Daniel J.en_US
dc.contributor.authorSchultz, Nikolausen_US
dc.contributor.authorShen, Ronglaien_US
dc.contributor.authorWeinhold, Nilsen_US
dc.contributor.authorKelsen, David P.en_US
dc.contributor.authorBowlby, Reanneen_US
dc.contributor.authorChu, Andyen_US
dc.contributor.authorKasaian, Katayoonen_US
dc.contributor.authorMungall, Andrew J.en_US
dc.contributor.authorRobertson, A. Gordonen_US
dc.contributor.authorSipahimalani, Payalen_US
dc.contributor.authorCherniack, Andrewen_US
dc.contributor.authorGetz, Gaden_US
dc.contributor.authorLiu, Yingchunen_US
dc.contributor.authorNoble, Michael S.en_US
dc.contributor.authorPedamallu, Chandraen_US
dc.contributor.authorSougnez, Carrieen_US
dc.contributor.authorTaylor-Weiner, Amaroen_US
dc.contributor.authorAkbani, Rehanen_US
dc.contributor.authorLee, Ju-Seogen_US
dc.contributor.authorLiu, Wenbinen_US
dc.contributor.authorMills, Gordon B.en_US
dc.contributor.authorYang, Daen_US
dc.contributor.authorZhang, Weien_US
dc.contributor.authorPantazi, Angelikien_US
dc.contributor.authorParfenov, Michaelen_US
dc.contributor.authorGulley, Margareten_US
dc.contributor.authorPiazuelo, M. Blancaen_US
dc.contributor.authorSchneider, Barbara G.en_US
dc.contributor.authorKim, Jihunen_US
dc.contributor.authorBoussioutas, Alexen_US
dc.contributor.authorSheth, Margien_US
dc.contributor.authorDemchok, John A.en_US
dc.contributor.authorRabkin, Charles S.en_US
dc.contributor.authorWillis, Joseph E.en_US
dc.contributor.authorNg, Samen_US
dc.contributor.authorGarman, Katherineen_US
dc.contributor.authorBeer, David G.en_US
dc.contributor.authorPennathur, Arjunen_US
dc.contributor.authorRaphael, Benjamin J.en_US
dc.contributor.authorWu, Hsin-Taen_US
dc.contributor.authorOdze, Roberten_US
dc.contributor.authorKim, Hark K.en_US
dc.contributor.authorBowen, Jayen_US
dc.contributor.authorLeraas, Kristen M.en_US
dc.contributor.authorLichtenberg, Tara M.en_US
dc.contributor.authorWeaver, Stephanieen_US
dc.contributor.authorMcLellan, Michaelen_US
dc.contributor.authorWiznerowicz, Maciejen_US
dc.contributor.authorSakai, Ryoen_US
dc.contributor.authorLawrence, Michael S.en_US
dc.contributor.authorCibulskis, Kristianen_US
dc.contributor.authorLichtenstein, Leeen_US
dc.contributor.authorFisher, Sheilaen_US
dc.contributor.authorGabriel, Stacey B.en_US
dc.contributor.authorLander, Eric S.en_US
dc.contributor.authorDing, Lien_US
dc.contributor.authorNiu, Beifangen_US
dc.contributor.authorAlly, Adrianen_US
dc.contributor.authorBalasundaram, Mirunaen_US
dc.contributor.authorBirol, Inancen_US
dc.contributor.authorBrooks, Deniseen_US
dc.contributor.authorButterfield, Yaron S. N.en_US
dc.contributor.authorCarlsen, Rebeccaen_US
dc.contributor.authorChu, Justinen_US
dc.contributor.authorChuah, Ericen_US
dc.contributor.authorChun, Hye-Jung E.en_US
dc.contributor.authorClarke, Amandaen_US
dc.contributor.authorDhalla, Noreenen_US
dc.contributor.authorGuin, Ranabiren_US
dc.contributor.authorHolt, Robert A.en_US
dc.contributor.authorJones, Steven J.M.en_US
dc.contributor.authorLee, Darleneen_US
dc.contributor.authorLi, Haiyan A.en_US
dc.contributor.authorLim, Emiliaen_US
dc.contributor.authorMa, Yussanneen_US
dc.contributor.authorMarra, Marco A.en_US
dc.contributor.authorMayo, Michaelen_US
dc.contributor.authorMoore, Richard A.en_US
dc.contributor.authorMungall, Karen L.en_US
dc.contributor.authorNip, Ka Mingen_US
dc.contributor.authorSchein, Jacqueline E.en_US
dc.contributor.authorTam, Angelaen_US
dc.contributor.authorThiessen, Ninaen_US
dc.contributor.authorBeroukhim, Rameenen_US
dc.contributor.authorCarter, Scott L.en_US
dc.contributor.authorCherniack, Andrew D.en_US
dc.contributor.authorCho, Juoken_US
dc.contributor.authorDiCara, Danielen_US
dc.contributor.authorFrazer, Scotten_US
dc.contributor.authorGehlenborg, Nilsen_US
dc.contributor.authorHeiman, David I.en_US
dc.contributor.authorJung, Joonilen_US
dc.contributor.authorKim, Jaegilen_US
dc.contributor.authorLin, Peien_US
dc.contributor.authorMeyerson, Matthewen_US
dc.contributor.authorOjesina, Akinyemi I.en_US
dc.contributor.authorPedamallu, Chandra Sekharen_US
dc.contributor.authorSaksena, Gordonen_US
dc.contributor.authorSchumacher, Steven E.en_US
dc.contributor.authorStojanov, Petaren_US
dc.contributor.authorTabak, Barbaraen_US
dc.contributor.authorVoet, Dougen_US
dc.contributor.authorRosenberg, Maraen_US
dc.contributor.authorZack, Travis I.en_US
dc.contributor.authorZhang, Haileien_US
dc.contributor.authorZou, Lihuaen_US
dc.contributor.authorProtopopov, Alexeien_US
dc.contributor.authorSantoso, Nettyen_US
dc.contributor.authorLee, Seminen_US
dc.contributor.authorZhang, Jianhuaen_US
dc.contributor.authorMahadeshwar, Harshad S.en_US
dc.contributor.authorTang, Jiabinen_US
dc.contributor.authorRen, Xiaojiaen_US
dc.contributor.authorSeth, Sahilen_US
dc.contributor.authorYang, Lixingen_US
dc.contributor.authorXu, Andrew W.en_US
dc.contributor.authorSong, Xingzhien_US
dc.contributor.authorXi, Ruibinen_US
dc.contributor.authorBristow, Christopher A.en_US
dc.contributor.authorHadjipanayis, Angelaen_US
dc.contributor.authorSeidman, Jonathanen_US
dc.contributor.authorChin, Lyndaen_US
dc.contributor.authorPark, Peter J.en_US
dc.contributor.authorKucherlapati, Rajuen_US
dc.contributor.authorLing, Shiyunen_US
dc.contributor.authorRao, Arvinden_US
dc.contributor.authorWeinstein, John N.en_US
dc.contributor.authorKim, Sang-Baeen_US
dc.contributor.authorLu, Yilingen_US
dc.contributor.authorMills, Gordonen_US
dc.contributor.authorBootwalla, Moiz S.en_US
dc.contributor.authorLai, Phillip H.en_US
dc.contributor.authorTriche, Timothyen_US
dc.contributor.authorVan Den Berg, David J.en_US
dc.contributor.authorBaylin, Stephen B.en_US
dc.contributor.authorHerman, James G.en_US
dc.contributor.authorMurray, Bradley A.en_US
dc.contributor.authorAskoy, B. Armanen_US
dc.contributor.authorCiriello, Giovannien_US
dc.contributor.authorDresdner, Gideonen_US
dc.contributor.authorGao, Jianjiongen_US
dc.contributor.authorGross, Benjaminen_US
dc.contributor.authorJacobsen, Andersen_US
dc.contributor.authorLee, Williamen_US
dc.contributor.authorRamirez, Ricardoen_US
dc.contributor.authorSander, Chrisen_US
dc.contributor.authorSenbabaoglu, Yasinen_US
dc.contributor.authorSinha, Rileenen_US
dc.contributor.authorSumer, S. Onuren_US
dc.contributor.authorSun, Yichaoen_US
dc.contributor.authorThorsson, Vésteinnen_US
dc.contributor.authorIype, Lisaen_US
dc.contributor.authorKramer, Roger W.en_US
dc.contributor.authorKreisberg, Richarden_US
dc.contributor.authorRovira, Hectoren_US
dc.contributor.authorTasman, Natalieen_US
dc.contributor.authorNg, Santa Cruz Samen_US
dc.contributor.authorHaussler, Daviden_US
dc.contributor.authorStuart, Josh M.en_US
dc.contributor.authorVerhaak, Roeland G.W.en_US
dc.contributor.authorLeiserson, Mark D. M.en_US
dc.contributor.authorTaylor, Barry S.en_US
dc.contributor.authorBlack, Aaron D.en_US
dc.contributor.authorCarney, Julie Annen_US
dc.contributor.authorGastier-Foster, Julie M.en_US
dc.contributor.authorHelsel, Carmenen_US
dc.contributor.authorMcAllister, Cynthiaen_US
dc.contributor.authorRamirez, Nilsa C.en_US
dc.contributor.authorTabler, Teresa R.en_US
dc.contributor.authorWise, Lisaen_US
dc.contributor.authorZmuda, Eriken_US
dc.contributor.authorPenny, Roberten_US
dc.contributor.authorCrain, Danielen_US
dc.contributor.authorGardner, Johannaen_US
dc.contributor.authorLau, Kevinen_US
dc.contributor.authorCurely, Erinen_US
dc.contributor.authorMallery, Daviden_US
dc.contributor.authorMorris, Scotten_US
dc.contributor.authorPaulauskis, Josephen_US
dc.contributor.authorShelton, Troyen_US
dc.contributor.authorShelton, Candaceen_US
dc.contributor.authorSherman, Marken_US
dc.contributor.authorBenz, Christopheren_US
dc.contributor.authorLee, Jae-Hyuken_US
dc.contributor.authorFedosenko, Konstantinen_US
dc.contributor.authorManikhas, Georgyen_US
dc.contributor.authorPotapova, Olgaen_US
dc.contributor.authorVoronina, Olgaen_US
dc.contributor.authorBelyaev, Smitryen_US
dc.contributor.authorDolzhansky, Olegen_US
dc.contributor.authorRathmell, W. Kimrynen_US
dc.contributor.authorBrzezinski, Jakuben_US
dc.contributor.authorIbbs, Matthewen_US
dc.contributor.authorKorski, Konstantyen_US
dc.contributor.authorKycler, Witolden_US
dc.contributor.authorŁaŸniak, Radoslawen_US
dc.contributor.authorLeporowska, Ewaen_US
dc.contributor.authorMackiewicz, Andrzejen_US
dc.contributor.authorMurawa, Dawiden_US
dc.contributor.authorMurawa, Pawelen_US
dc.contributor.authorSpychała, Arkadiuszen_US
dc.contributor.authorSuchorska, Wiktoria M.en_US
dc.contributor.authorTatka, Honorataen_US
dc.contributor.authorTeresiak, Mareken_US
dc.contributor.authorAbdel-Misih, Raafaten_US
dc.contributor.authorBennett, Josephen_US
dc.contributor.authorBrown, Jenniferen_US
dc.contributor.authorIacocca, Maryen_US
dc.contributor.authorRabeno, Brendaen_US
dc.contributor.authorKwon, Sun-Youngen_US
dc.contributor.authorKemkes, Arianeen_US
dc.contributor.authorCurley, Erinen_US
dc.contributor.authorAlexopoulou, Iakovinaen_US
dc.contributor.authorEngel, Jayen_US
dc.contributor.authorBartlett, Johnen_US
dc.contributor.authorAlbert, Moniqueen_US
dc.contributor.authorPark, Do-Younen_US
dc.contributor.authorDhir, Rajiven_US
dc.contributor.authorLuketich, Jamesen_US
dc.contributor.authorLandreneau, Rodneyen_US
dc.contributor.authorJanjigian, Yelena Y.en_US
dc.contributor.authorCho, Eunjungen_US
dc.contributor.authorLadanyi, Marcen_US
dc.contributor.authorTang, Lauraen_US
dc.contributor.authorMcCall, Shannon J.en_US
dc.contributor.authorPark, Young S.en_US
dc.contributor.authorCheong, Jae-Hoen_US
dc.contributor.authorAjani, Jafferen_US
dc.contributor.authorCamargo, M. Constanzaen_US
dc.contributor.authorAlonso, Shelleyen_US
dc.contributor.authorAyala, Brendaen_US
dc.contributor.authorJensen, Mark A.en_US
dc.contributor.authorPihl, Todden_US
dc.contributor.authorRaman, Rohinien_US
dc.contributor.authorWalton, Jessicaen_US
dc.contributor.authorWan, Yunhuen_US
dc.contributor.authorEley, Gregen_US
dc.contributor.authorMills Shaw, Kenna R.en_US
dc.contributor.authorTarnuzzer, Royen_US
dc.contributor.authorWang, Zhiningen_US
dc.contributor.authorYang, Limingen_US
dc.contributor.authorZenklusen, Jean Claudeen_US
dc.contributor.authorDavidsen, Tanjaen_US
dc.contributor.authorHutter, Carolyn M.en_US
dc.contributor.authorSofia, Heidi J.en_US
dc.contributor.authorBurton, Roberten_US
dc.contributor.authorChudamani, Sudhaen_US
dc.contributor.authorLiu, Jiaen_US
dc.date.accessioned2014-10-01T14:29:01Z
dc.date.issued2014en_US
dc.identifier.citationBass, A. J., V. Thorsson, I. Shmulevich, S. M. Reynolds, M. Miller, B. Bernard, T. Hinoue, et al. 2014. “Comprehensive molecular characterization of gastric adenocarcinoma.” Nature 513 (7517): 202-209. doi:10.1038/nature13480. http://dx.doi.org/10.1038/nature13480.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12987344
dc.description.abstractGastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature13480en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170219/pdf/en
dash.licenseLAAen_US
dc.titleComprehensive molecular characterization of gastric adenocarcinomaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorPantazi, Angelikien_US
dc.date.available2014-10-01T14:29:01Z
dc.identifier.doi10.1038/nature13480*
dash.authorsorderedfalse
dash.contributor.affiliatedParfenov, Michael
dash.contributor.affiliatedPantazi, Angeliki
dash.contributor.affiliatedOdze, Robert
dash.contributor.affiliatedLee, Semin
dash.contributor.affiliatedHadjipanayis, Angela
dash.contributor.affiliatedYang, Lixing
dash.contributor.affiliatedPark, Peter
dash.contributor.affiliatedSeidman, Jonathan
dash.contributor.affiliatedKucherlapati, Raju


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