Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy

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Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy

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Title: Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy
Author: Soiza-Reilly, Mariano; Commons, Kathryn G.

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Citation: Soiza-Reilly, Mariano, and Kathryn G. Commons. 2014. “Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy.” Frontiers in Neural Circuits 8 (1): 105. doi:10.3389/fncir.2014.00105. http://dx.doi.org/10.3389/fncir.2014.00105.
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Abstract: The dorsal raphe nucleus (DRN), representing the main source of brain’s serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism. The activity of DRN neurons is precisely regulated, both phasically and tonically, by excitatory glutamate and inhibitory GABAergic axons arising from extra-raphe areas as well as from local sources within the nucleus. Changes in serotonin neurotransmission associated with pathophysiology may be encoded by alterations within this network of regulatory afferents. However, the complex organization of the DRN circuitry remains still poorly understood. Using a recently developed high-resolution immunofluorescence technique called array tomography (AT) we quantitatively analyzed the relative contribution of different populations of glutamate axons originating from different brain regions to the excitatory drive of the DRN. Additionally, we examined the presence of GABA axons within the DRN and their possible association with glutamate axons. In this review, we summarize our findings on the architecture of the rodent DRN synaptic neuropil using high-resolution neuroanatomy, and discuss possible functional implications for the nucleus. Understanding of the synaptic architecture of neural circuits at high resolution will pave the way to understand how neural structure and function may be perturbed in pathological states.
Published Version: doi:10.3389/fncir.2014.00105
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143723/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12987380
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