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dc.contributor.authorKim, In-Jung
dc.contributor.authorZhang, Yifeng
dc.contributor.authorMeister, Markus
dc.contributor.authorSanes, Joshua R.
dc.date.accessioned2014-10-14T19:32:10Z
dc.date.issued2010
dc.identifier.citationKim, In-Jung, Yifeng Zhang, Markus Meister, and Joshua R. Sanes. 2010. Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers. Journal of Neuroscience 30, no. 4: 1452–1462.en_US
dc.identifier.issn0270-6474en_US
dc.identifier.issn1529-2401en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13041315
dc.description.abstractRetinal ganglion cells (RGCs), which transfer information from the eye to the brain, are heterogeneous in structure and function, but developmental studies have generally treated them as a single group. Here, we investigate the development of RGC axonal and dendritic arbors using four mouse transgenic lines in which nonoverlapping subsets of RGCs are indelibly labeled with a fluorescent protein. Each subset has a distinct functional signature, size, and morphology. Dendrites of each subset are restricted to specific sublaminae within the inner plexiform layer in adulthood, but acquire their restriction in different ways: one subset has lamina-restricted dendrites from an early postnatal stage, a second remodels an initially diffuse pattern, and two others develop stepwise. Axons of each subset arborize in discrete laminar zones within the lateral geniculate nucleus or superior colliculus, demonstrating previously unrecognized subdivisions of retinorecipient layers. As is the case for dendrites, lamina-restricted axonal projections of RGC subsets develop in different ways. For example, while axons of two RGC subsets arborize in definite zones of the superior colliculus from an early postnatal stage, axons of another subset initially occupy a deep layer, then translocate to a narrow subpial zone. Together, these results show that RGC subsets use a variety of strategies to construct lamina-restricted dendritic and axonal arbors. Taking account of these subtype-specific features will facilitate identification of the molecules and cells that regulate arbor formation.en_US
dc.description.sponsorshipMolecular and Cellular Biologyen_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofdoi:10.1523/JNEUROSCI.4779-09.2010en_US
dash.licenseLAA
dc.titleLaminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Neuroscienceen_US
dash.depositing.authorSanes, Joshua R.
dc.date.available2014-10-14T19:32:10Z
dc.identifier.doi10.1523/JNEUROSCI.4779-09.2010*
workflow.legacycommentsFAR 2011 per sherpa can post pub with six month embargo, which has long since expired.en_US
dash.contributor.affiliatedSanes, Joshua
dash.contributor.affiliatedMeister, Markus


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