Generation of pluripotent stem cells from patients with type 1 diabetes

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Generation of pluripotent stem cells from patients with type 1 diabetes

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Title: Generation of pluripotent stem cells from patients with type 1 diabetes
Author: Maehr, René; Chen, Shuibing; Snitow, Melinda; Ludwig, Thomas; Yagasaki, Lisa; Goland, Robin; Leibel, Rudolph L.; Melton, Douglas A.

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Citation: Maehr, René, S. Chen, M. Snitow, T. Ludwig, L. Yagasaki, R. Goland, R. L. Leibel, and Douglas A. Melton. 2009. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences 106(37): 15768-15773.
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Abstract: Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
Published Version: doi:10.1073/pnas.0906894106
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735559/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13064993
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