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dc.contributor.authorMallarino, Ricardo
dc.contributor.authorCampas, O.
dc.contributor.authorFritz, Joerg
dc.contributor.authorBurns, K. J.
dc.contributor.authorWeeks, Olivia Grace
dc.contributor.authorBrenner, Michael P.
dc.contributor.authorAbzhanov, Arkhat
dc.date.accessioned2014-10-21T17:28:38Z
dc.date.issued2012
dc.identifierQuick submit: 2014-02-14T13:59:14-05:00
dc.identifier.citationMallarino, R., O. Campas, J. A. Fritz, K. J. Burns, O. G. Weeks, M. P. Brenner, and A. Abzhanov. 2012. “Closely Related Bird Species Demonstrate Flexibility Between Beak Morphology and Underlying Developmental Programs.” Proceedings of the National Academy of Sciences 109 (40) (October 2): 16222–16227.en_US
dc.identifier.issn1091-6490en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13065016
dc.description.abstractThe astonishing variation in the shape and size of bird beaks reflects a wide range of dietary specializations that played an important role in avian diversification. Among Darwin's finches, ground finches (Geospiza spp.) have beaks that represent scaling variations of the same shape, which are generated by alterations in the signaling pathways that regulate growth of the two skeletal components of the beak: the prenasal cartilage (pnc) and the premaxillary bone (pmx). Whether this developmental mechanism is responsible for variation within groups of other closely related bird species, however, has remained unknown. Here, we report that the Caribbean bullfinches (Loxigilla spp.), which are closely related to Darwin's finches, have independently evolved beaks of a novel shape, different from Geospiza, but also varying from each other only in scaling. However, despite sharing the same beak shape, the signaling pathways and tissues patterning Loxigilla beaks differ among the three species. In Loxigilla noctis, as in Geospiza, the pnc develops first, shaped by Bmp4 and CaM signaling, followed by the development of the pmx, regulated by TGFβIIr, β-catenin, and Dkk3 signaling. In contrast, beak morphogenesis in Loxigilla violacea and Loxigilla portoricensis is generated almost exclusively by the pmx through a mechanism in which Ihh and Bmp4 synergize to promote expansion of bone tissue. Together, our results demonstrate high flexibility in the relationship between morphology and underlying developmental causes, where different developmental programs can generate identical shapes, and similar developmental programs can pattern different shapes.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.1206205109en_US
dash.licenseLAA
dc.titleClosely related bird species demonstrate flexibility between beak morphology and underlying developmental programsen_US
dc.typeJournal Articleen_US
dc.date.updated2014-02-14T19:00:50Z
dc.description.versionVersion of Recorden_US
dc.rights.holderArhat Abzhanov
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorAbzhanov, Arkhat
dash.waiver2012-08-05
dc.date.available2014-10-21T17:28:38Z
dc.identifier.doi10.1073/pnas.1206205109*
workflow.legacycommentsPer new OSC interpretation can post pub.en_US
dash.contributor.affiliatedWeeks, Olivia
dash.contributor.affiliatedFritz, Joerg
dash.contributor.affiliatedMallarino, Ricardo
dash.contributor.affiliatedAbzhanov, Arkhat
dash.contributor.affiliatedBrenner, Michael


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