A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics

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A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics

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Title: A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics
Author: Li, Xin; Yang, Chengyu; Wu, Kai; Hu, Yongzhou; Han, Yifeng; Liang, Steven H.

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Citation: Li, Xin, Chengyu Yang, Kai Wu, Yongzhou Hu, Yifeng Han, and Steven H. Liang. 2014. “A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics.” Theranostics 4 (12): 1233-1238. doi:10.7150/thno.10330. http://dx.doi.org/10.7150/thno.10330.
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Abstract: Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H2S) in live cells. The detection system is selective for complicated biological application and the response is fast enough to complete within seconds. Moreover, the probe exhibits the unique advantage of being immune to aggregation-caused quenching which is a detrimental phenomenon limiting the application of most current available H2S fluorescent probes. The detection mechanism was investigated and postulated to be S2- initiated de-coordination and thereafter aggregation of the AIE-S complex.
Published Version: doi:10.7150/thno.10330
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184000/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347393
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