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dc.contributor.authorValentino, Michael D.en_US
dc.contributor.authorFoulston, Lucyen_US
dc.contributor.authorSadaka, Amaen_US
dc.contributor.authorKos, Veronica N.en_US
dc.contributor.authorVillet, Regis A.en_US
dc.contributor.authorSanta Maria, Johnen_US
dc.contributor.authorLazinski, David W.en_US
dc.contributor.authorCamilli, Andrewen_US
dc.contributor.authorWalker, Suzanneen_US
dc.contributor.authorHooper, David C.en_US
dc.contributor.authorGilmore, Michael S.en_US
dc.date.accessioned2014-11-03T17:38:09Z
dc.date.issued2014en_US
dc.identifier.citationValentino, M. D., L. Foulston, A. Sadaka, V. N. Kos, R. A. Villet, J. Santa Maria, D. W. Lazinski, et al. 2014. “Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies.” mBio 5 (5): e01729-14. doi:10.1128/mBio.01729-14. http://dx.doi.org/10.1128/mBio.01729-14.en
dc.identifier.issn2150-7511en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347407
dc.description.abstractABSTRACT Staphylococcus aureus is a leading cause of both community- and hospital-acquired infections that are increasingly antibiotic resistant. The emergence of S. aureus resistance to even last-line antibiotics heightens the need for the development of new drugs with novel targets. We generated a highly saturated transposon insertion mutant library in the genome of S. aureus and used Tn-seq analysis to probe the entire genome, with unprecedented resolution and sensitivity, for genes of importance in infection. We further identified genes contributing to fitness in various infected compartments (blood and ocular fluids) and compared them to genes required for growth in rich medium. This resulted in the identification of 426 genes that were important for S. aureus fitness during growth in infection models, including 71 genes that could be considered essential for survival specifically during infection. These findings highlight novel as well as previously known genes encoding virulence traits and metabolic pathways important for S. aureus proliferation at sites of infection, which may represent new therapeutic targets.en
dc.language.isoen_USen
dc.publisherAmerican Society of Microbiologyen
dc.relation.isversionofdoi:10.1128/mBio.01729-14en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173792/pdf/en
dash.licenseLAAen_US
dc.titleGenes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologiesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalmBioen
dash.depositing.authorFoulston, Lucyen_US
dc.date.available2014-11-03T17:38:09Z
dc.identifier.doi10.1128/mBio.01729-14*
dash.authorsorderedfalse
dash.contributor.affiliatedFoulston, Lucy
dash.contributor.affiliatedVillet, Regis A.
dash.contributor.affiliatedHooper, David


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