Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men

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Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men

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Title: Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men
Author: Sawada, Susumu S; Lee, I-Min; Naito, Hisashi; Kakigi, Ryo; Goto, Sataro; Kanazawa, Masaaki; Okamoto, Takashi; Tsukamoto, Koji; Muto, Takashi; Tanaka, Hiroaki; Blair, Steven N

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Citation: Sawada, S. S., I. Lee, H. Naito, R. Kakigi, S. Goto, M. Kanazawa, T. Okamoto, et al. 2014. “Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men.” BMC Public Health 14 (1): 1012. doi:10.1186/1471-2458-14-1012. http://dx.doi.org/10.1186/1471-2458-14-1012.
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Abstract: Background: The aim of this study is to investigate the independent and joint effects of cardiorespiratory fitness (CRF) and body mass index (BMI) on cancer mortality in a low body mass index population. Methods: We evaluated CRF and BMI in relation to cancer mortality in 8760 Japanese men. The median BMI was 22.6 kg/m2 (IQR: 21.0-24.3). The mean follow-up period was more than 20 years. Hazard ratios and 95% CI were obtained using a Cox proportional hazards model while adjusting for several confounding factors. Results: Using the 2nd tertile of BMI (21.6-23.6 kg/m2) as reference, hazard ratios and 95% CI for the lowest tertile of BMI (18.5-21.5) were 1.26 (0.87–1.81), and 0.92 (0.64–1.34) for the highest tertile (23.7-37.4). Using the lowest tertile of CRF as reference, hazard ratios and 95% CIs for 2nd and highest tertiles of CRF were 0.78 (0.55–1.10) and 0.59 (0.40–0.88). We further calculated hazard ratios according to groups of men cross-tabulated by tertiles of CRF and BMI. Among men in the second tertile of BMI, those belonging to the lowest CRF tertile had a 53% lower risk of cancer mortality compared to those in the lowest CRF tertile (hazard ratio: 0.47, 95% CI: 0.23-0.97). Among those in the highest BMI tertile, the corresponding hazard ratio was 0.54 (0.25-1.17). Conclusion: These results suggest that high CRF is associated with lower cancer mortality in a Japanese population of men with low average BMI.
Published Version: doi:10.1186/1471-2458-14-1012
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190338/pdf/
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Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347420
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