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dc.contributor.authorChen, Ling-Weien_US
dc.contributor.authorWu, Yien_US
dc.contributor.authorNeelakantan, Nithyaen_US
dc.contributor.authorChong, Mary Foong-Fongen_US
dc.contributor.authorPan, Anen_US
dc.contributor.authorvan Dam, Rob Men_US
dc.date.accessioned2014-11-03T17:38:50Z
dc.date.issued2014en_US
dc.identifier.citationChen, Ling-Wei, Yi Wu, Nithya Neelakantan, Mary Foong-Fong Chong, An Pan, and Rob M van Dam. 2014. “Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose–response meta-analysis.” BMC Medicine 12 (1): 174. doi:10.1186/s12916-014-0174-6. http://dx.doi.org/10.1186/s12916-014-0174-6.en
dc.identifier.issn1741-7015en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347461
dc.description.abstractBackground: Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g). We aim to assess this association using a systematic review and dose–response meta-analysis of prospective studies. Methods: Potential articles were identified by searching MEDLINE and SCOPUS databases through 17 July 2013. Two authors independently extracted information on study design, participant characteristics and estimates of associations. Random-effects models were used to derive the summary relative risks (RRs) and corresponding 95% confidence intervals (CIs). Dose–response relationships were assessed using generalized least-squares trend estimation. Results: In our meta-analysis, we included 13 prospective studies: 9 with low birth weight as a binary outcome variable (90,747 participants and 6,303 cases) and 6 with birth weight as a continuous outcome variable (10,015 participants; 2 studies reported both types of outcomes). Compared with the reference category with no or very low caffeine intake, the RR (95% CI) of low birth weight was 1.13 (1.06 to 1.21; I2 0.0%) for low intake (50 to 149 mg/day), 1.38 (1.18 to 1.62; I2 31.9%) for moderate intake (150 to 349 mg/day), and 1.60 (1.24 to 2.08; I2 65.8%) for high intake (≥350 mg/day). In the dose–response analysis, each 100-mg/day increment in maternal caffeine intake (around one cup of coffee) was associated with 13% (RR 1.13, 1.06 to 1.21) higher risk of low birth weight. The association persisted in strata defined according to various study characteristics. Moderate (−33 g, 95% CI −63 to −4; I2 0.3%) and high (−69 g, 95% CI −102 to −35; I2 0.0%) caffeine intakes were also associated with a significantly lower birth weight as compared with the reference category. Conclusions: Higher maternal caffeine intake during pregnancy was associated with a higher risk of delivering low birth weight infants. These findings support recommendations to restrict caffeine intake during pregnancy to low levels. Electronic supplementary material The online version of this article (doi:10.1186/s12916-014-0174-6) contains supplementary material, which is available to authorized users.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12916-014-0174-6en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198801/pdf/en
dash.licenseLAAen_US
dc.subjectCoffeeen
dc.subjectCaffeineen
dc.subjectLow birth weighten
dc.subjectSmall for gestational ageen
dc.subjectIntrauterine growth restrictionen
dc.subjectSystematic reviewen
dc.subjectMeta-analysisen
dc.titleMaternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose–response meta-analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Medicineen
dash.depositing.authorvan Dam, Rob Men_US
dc.date.available2014-11-03T17:38:50Z
dc.identifier.doi10.1186/s12916-014-0174-6*
dash.contributor.affiliatedVan Dam, Rob


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