Show simple item record

dc.contributor.authorSantiago, Jose A.en_US
dc.contributor.authorScherzer, Clemens R.en_US
dc.contributor.authorPotashkin, Judith A.en_US
dc.date.accessioned2014-11-03T17:39:34Z
dc.date.issued2014en_US
dc.identifier.citationSantiago, Jose A., Clemens R. Scherzer, and Judith A. Potashkin. 2014. “Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease.” PLoS ONE 9 (10): e109042. doi:10.1371/journal.pone.0109042. http://dx.doi.org/10.1371/journal.pone.0109042.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347518
dc.description.abstractIncreasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. We identified 84 genes shared between PD and T2DM from curated disease-gene databases. Nitric oxide biosynthesis, lipid and carbohydrate metabolism, insulin secretion and inflammation were identified as common dysregulated pathways. A network prioritization approach was implemented to rank genes according to their distance to seed genes and their involvement in common biological pathways. Quantitative polymerase chain reaction assays revealed that a highly ranked gene, superoxide dismutase 2 (SOD2), is upregulated in PD patients compared to healthy controls in 192 whole blood samples from two independent clinical trials, the Harvard Biomarker Study (HBS) and the Diagnostic and Prognostic Biomarkers in Parkinson's disease (PROBE). The results from this study reinforce the idea that shared molecular networks between PD and T2DM provides an additional source of biologically meaningful biomarkers. Evaluation of this biomarker in de novo PD patients and in a larger prospective longitudinal study is warranted.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0109042en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184821/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectNeuroscienceen
dc.subjectSystems Biologyen
dc.subjectMedicine and Health Sciencesen
dc.subjectDiagnostic Medicineen
dc.subjectMetabolic Disordersen
dc.subjectNeurologyen
dc.titleNetwork Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorScherzer, Clemens R.en_US
dc.date.available2014-11-03T17:39:34Z
dc.identifier.doi10.1371/journal.pone.0109042*
dash.contributor.affiliatedScherzer, Clemens


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record