Temporal Course of the Tourette Syndrome Clinical Triad

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Temporal Course of the Tourette Syndrome Clinical Triad

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Title: Temporal Course of the Tourette Syndrome Clinical Triad
Author: Shprecher, David R.; Rubenstein, Lindsay A.; Gannon, Keenan; Frank, Samuel A.; Kurlan, Roger

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Citation: Shprecher, David R., Lindsay A. Rubenstein, Keenan Gannon, Samuel A. Frank, and Roger Kurlan. 2014. “Temporal Course of the Tourette Syndrome Clinical Triad.” Tremor and Other Hyperkinetic Movements 4 (1): 243. doi:10.7916/D8HD7SV6. http://dx.doi.org/10.7916/D8HD7SV6.
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Abstract: Background: Tourette syndrome (TS) is a disorder characterized by childhood onset of motor and phonic tics, often with improvement of tic symptoms by young adult years. The temporal course of tics and commonly comorbid behavioral symptoms is still not well characterized. Methods: In order to clarify the time course of tics and comorbid attention deficit hyperactivity disorder (ADHD) or obsessive compulsive disorder (OCD) in TS, we administered a brief survey regarding the course of symptoms at a single point in time to 53 TS patients aged 13–31 years. Results: Mean age (±SD) at symptom onset was 7.9 (±3.6) years for tics, 7.9 (±3.5) for ADHD, and 9.2 (±5.0) for OCD. Age at peak symptom severity was 12.3 (±4.6) years for tics, 10.8 (±3.8) for ADHD, and 12.6 (±5.5) for OCD. Tics, ADHD, and OCD were reported to be no longer present in 32.0%, 22.8%, and 21.0% of subjects, respectively. Decline in symptom severity began at age 14.7 (±3.7) years for tics, 13.9 (±2.9) for ADHD, and 15.1 (±5.0) for OCD. Remission of symptoms occurred at age 17.4 (±3.8) years for tics, 17.4 (±1.3) for ADHD, and 15.6 (±2.3) for OCD. Discussion Our data confirm and expand previously reported TS spectrum symptom milestones and may guide design of future research aimed at improving the course of TS.
Published Version: doi:10.7916/D8HD7SV6
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185327/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347521
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