Ubiquitin Signaling: Extreme Conservation as a Source of Diversity

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Ubiquitin Signaling: Extreme Conservation as a Source of Diversity

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Title: Ubiquitin Signaling: Extreme Conservation as a Source of Diversity
Author: Zuin, Alice; Isasa, Marta; Crosas, Bernat

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Citation: Zuin, Alice, Marta Isasa, and Bernat Crosas. 2014. “Ubiquitin Signaling: Extreme Conservation as a Source of Diversity.” Cells 3 (3): 690-701. doi:10.3390/cells3030690. http://dx.doi.org/10.3390/cells3030690.
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Abstract: Around 2 × 103–2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same functionally capable ubiquitin molecule that all eukaryotic species contain today. The fact that ubiquitin protein has virtually not changed during all eukaryotic evolution contrasts with the high expansion of the ubiquitin system, constituted by hundreds of enzymes, ubiquitin-interacting proteins, protein complexes, and cofactors. Interestingly, the simplest genetic arrangement encoding a fully-equipped ubiquitin signaling system is constituted by five genes organized in an operon-like cluster, and is found in archaea. How did ubiquitin achieve the status of central element in eukaryotic physiology? We analyze here the features of the ubiquitin molecule and the network that it conforms, and propose notions to explain the complexity of the ubiquitin signaling system in eukaryotic cells.
Published Version: doi:10.3390/cells3030690
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197634/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347556
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