Show simple item record

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

dc.contributor.authorSpringelkamp, Henriët.en_US
dc.contributor.authorHöhn, Renéen_US
dc.contributor.authorMishra, Aniketen_US
dc.contributor.authorHysi, Pirro G.en_US
dc.contributor.authorKhor, Chiea-Chuenen_US
dc.contributor.authorLoomis, Stephanie J.en_US
dc.contributor.authorBailey, Jessica N. Cookeen_US
dc.contributor.authorGibson, Janeen_US
dc.contributor.authorThorleifsson, Gudmaren_US
dc.contributor.authorJanssen, Sarah F.en_US
dc.contributor.authorLuo, Xiaoyanen_US
dc.contributor.authorRamdas, Wishal D.en_US
dc.contributor.authorVithana, Erangaen_US
dc.contributor.authorNongpiur, Monisha E.en_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorXu, Liangen_US
dc.contributor.authorMountain, Jenny E.en_US
dc.contributor.authorGharahkhani, Puyaen_US
dc.contributor.authorLu, Yien_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorKarssen, Lennart C.en_US
dc.contributor.authorSim, Kar-Sengen_US
dc.contributor.authorvan Leeuwen, Elisabeth M.en_US
dc.contributor.authorIglesias, Adriana I.en_US
dc.contributor.authorVerhoeven, Virginie J. M.en_US
dc.contributor.authorHauser, Michael A.en_US
dc.contributor.authorLoon, Seng-Cheeen_US
dc.contributor.authorDespriet, Dominiek D. G.en_US
dc.contributor.authorNag, Abhisheken_US
dc.contributor.authorVenturini, Cristinaen_US
dc.contributor.authorSanfilippo, Paul G.en_US
dc.contributor.authorSchillert, Arneen_US
dc.contributor.authorKang, Jae H.en_US
dc.contributor.authorLanders, Johnen_US
dc.contributor.authorJonasson, Fridberten_US
dc.contributor.authorCree, Angela J.en_US
dc.contributor.authorvan Koolwijk, Leonieke M. E.en_US
dc.contributor.authorRivadeneira, Fernandoen_US
dc.contributor.authorSouzeau, Emmanuelleen_US
dc.contributor.authorJonsson, Vesteinnen_US
dc.contributor.authorMenon, Geetaen_US
dc.contributor.authorMitchell, Paulen_US
dc.contributor.authorWang, Jie Jinen_US
dc.contributor.authorRochtchina, Elenaen_US
dc.contributor.authorAttia, Johnen_US
dc.contributor.authorScott, Rodneyen_US
dc.contributor.authorHolliday, Elizabeth G.en_US
dc.contributor.authorWong, Tien-Yinen_US
dc.contributor.authorBaird, Paul N.en_US
dc.contributor.authorXie, Jingen_US
dc.contributor.authorInouye, Michaelen_US
dc.contributor.authorViswanathan, Ananthen_US
dc.contributor.authorSim, Xuelingen_US
dc.contributor.authorWeinreb, Robert N.en_US
dc.contributor.authorde Jong, Paulus T. V. M.en_US
dc.contributor.authorOostra, Ben A.en_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorEnnis, Sarahen_US
dc.contributor.authorThorsteinsdottir, Unnuren_US
dc.contributor.authorBurdon, Kathryn P.en_US
dc.contributor.authorAllingham, R. Randen_US
dc.contributor.authorBrilliant, Murray H.en_US
dc.contributor.authorBudenz, Donald L.en_US
dc.contributor.authorCooke Bailey, Jessica N.en_US
dc.contributor.authorChristen, William G.en_US
dc.contributor.authorFingert, Johnen_US
dc.contributor.authorFriedman, David S.en_US
dc.contributor.authorGaasterland, Douglasen_US
dc.contributor.authorGaasterland, Terryen_US
dc.contributor.authorHaines, Jonathan L.en_US
dc.contributor.authorKang, Jae Heeen_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorLee, Richard K.en_US
dc.contributor.authorLichter, Paul R.en_US
dc.contributor.authorLiu, Yutaoen_US
dc.contributor.authorMoroi, Sayoko E.en_US
dc.contributor.authorPasquale, Louis R.en_US
dc.contributor.authorPericak-Vance, Margaret A.en_US
dc.contributor.authorRealini, Anthonyen_US
dc.contributor.authorRichards, Julia E.en_US
dc.contributor.authorSchuman, Joel S.en_US
dc.contributor.authorScott, William K.en_US
dc.contributor.authorSingh, Kuldeven_US
dc.contributor.authorSit, Arthur J.en_US
dc.contributor.authorVollrath, Douglasen_US
dc.contributor.authorWiggs, Janey L.en_US
dc.contributor.authorWollstein, Gadien_US
dc.contributor.authorZack, Donald J.en_US
dc.contributor.authorZhang, Kangen_US
dc.contributor.authorDonnelly (Chair), Peteren_US
dc.contributor.authorBarroso (Deputy Chair), Inesen_US
dc.contributor.authorBlackwell, Jenefer M.en_US
dc.contributor.authorBramon, Elviraen_US
dc.contributor.authorBrown, Matthew A.en_US
dc.contributor.authorCasas, Juan P.en_US
dc.contributor.authorCorvin, Aidenen_US
dc.contributor.authorDeloukas, Panosen_US
dc.contributor.authorDuncanson, Audreyen_US
dc.contributor.authorJankowski, Januszen_US
dc.contributor.authorMarkus, Hugh S.en_US
dc.contributor.authorMathew, Christopher G.en_US
dc.contributor.authorPalmer, Colin N. A.en_US
dc.contributor.authorPlomin, Roberten_US
dc.contributor.authorRautanen, Annaen_US
dc.contributor.authorSawcer, Stephen J.en_US
dc.contributor.authorTrembath, Richard C.en_US
dc.contributor.authorViswanathan, Ananth C.en_US
dc.contributor.authorWood, Nicholas W.en_US
dc.contributor.authorSpencer, Chris C. A.en_US
dc.contributor.authorBand, Gavinen_US
dc.contributor.authorBellenguez, Célineen_US
dc.contributor.authorFreeman, Colinen_US
dc.contributor.authorHellenthal, Garretten_US
dc.contributor.authorGiannoulatou, Elenien_US
dc.contributor.authorPirinen, Mattien_US
dc.contributor.authorPearson, Richarden_US
dc.contributor.authorStrange, Amyen_US
dc.contributor.authorSu, Zhanen_US
dc.contributor.authorVukcevic, Damjanen_US
dc.contributor.authorDonnelly, Peteren_US
dc.contributor.authorLangford, Cordeliaen_US
dc.contributor.authorHunt, Sarah E.en_US
dc.contributor.authorEdkins, Sarahen_US
dc.contributor.authorGwilliam, Rhianen_US
dc.contributor.authorBlackburn, Hannahen_US
dc.contributor.authorBumpstead, Suzannah J.en_US
dc.contributor.authorDronov, Sergeen_US
dc.contributor.authorGillman, Matthewen_US
dc.contributor.authorGray, Emmaen_US
dc.contributor.authorHammond, Naomien_US
dc.contributor.authorJayakumar, Alagurevathien_US
dc.contributor.authorMcCann, Owen T.en_US
dc.contributor.authorLiddle, Jenniferen_US
dc.contributor.authorPotter, Simon C.en_US
dc.contributor.authorRavindrarajah, Radhien_US
dc.contributor.authorRicketts, Michelleen_US
dc.contributor.authorWaller, Matthewen_US
dc.contributor.authorWeston, Paulen_US
dc.contributor.authorWidaa, Saraen_US
dc.contributor.authorWhittaker, Pamelaen_US
dc.contributor.authorBarroso, Inesen_US
dc.contributor.authorMathew (Chair), Christopher G.en_US
dc.contributor.authorSpector, Timothy D.en_US
dc.contributor.authorMirshahi, Alirezaen_US
dc.contributor.authorSaw, Seang-Meien_US
dc.contributor.authorVingerling, Johannes R.en_US
dc.contributor.authorTeo, Yik-Yingen_US
dc.contributor.authorWolfs, Roger C. W.en_US
dc.contributor.authorLemij, Hans G.en_US
dc.contributor.authorTai, E-Shyongen_US
dc.contributor.authorJansonius, Nomdo M.en_US
dc.contributor.authorJonas, Jost B.en_US
dc.contributor.authorCheng, Ching-Yuen_US
dc.contributor.authorAung, Tinen_US
dc.contributor.authorKlaver, Caroline C. W.en_US
dc.contributor.authorCraig, Jamie E.en_US
dc.contributor.authorMacgregor, Stuarten_US
dc.contributor.authorMackey, David A.en_US
dc.contributor.authorLotery, Andrew J.en_US
dc.contributor.authorStefansson, Karien_US
dc.contributor.authorBergen, Arthur A. B.en_US
dc.contributor.authorYoung, Terri L.en_US
dc.contributor.authorPfeiffer, Norberten_US
dc.contributor.authorHewitt, Alex W.en_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorHammond, Christopher J.en_US
dc.date.accessioned2014-11-03T17:40:02Z
dc.date.issued2014en_US
dc.identifier.citationSpringelkamp, H., R. Höhn, A. Mishra, P. G. Hysi, C. Khor, S. J. Loomis, J. N. C. Bailey, et al. 2014. “Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.” Nature Communications 5 (1): 4883. doi:10.1038/ncomms5883. http://dx.doi.org/10.1038/ncomms5883.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347568
dc.description.abstractGlaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.en
dc.language.isoen_USen
dc.publisherNature Pub. Groupen
dc.relation.isversionofdoi:10.1038/ncomms5883en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199103/pdf/en
dash.licenseLAAen_US
dc.titleMeta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous processen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorKang, Jae Heeen_US
dc.date.available2014-11-03T17:40:02Z
dc.identifier.doi10.1038/ncomms5883*
dash.authorsorderedfalse
dash.contributor.affiliatedPasquale, Louis
dash.contributor.affiliatedKang, Jae Hee
dash.contributor.affiliatedWiggs, Janey


Files in this item

Thumbnail
Name:
4199103.pdf
Size:
481.2Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record