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dc.contributor.authorCebrián, Carolinaen_US
dc.contributor.authorZucca, Fabio A.en_US
dc.contributor.authorMauri, Pierluigien_US
dc.contributor.authorSteinbeck, Julius A.en_US
dc.contributor.authorStuder, Lorenzen_US
dc.contributor.authorScherzer, Clemens R.en_US
dc.contributor.authorKanter, Ellenen_US
dc.contributor.authorBudhu, Sadnaen_US
dc.contributor.authorMandelbaum, Jonathanen_US
dc.contributor.authorVonsattel, Jean P.en_US
dc.contributor.authorZecca, Luigien_US
dc.contributor.authorLoike, John D.en_US
dc.contributor.authorSulzer, Daviden_US
dc.date.accessioned2014-11-03T17:40:21Z
dc.date.issued2014en_US
dc.identifier.citationCebrián, C., F. A. Zucca, P. Mauri, J. A. Steinbeck, L. Studer, C. R. Scherzer, E. Kanter, et al. 2014. “MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.” Nature communications 5 (1): 3633. doi:10.1038/ncomms4633. http://dx.doi.org/10.1038/ncomms4633.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347601
dc.description.abstractSubsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA expression, and mass spectrometry analysis of postmortem samples that human catecholaminergic substantia nigra and locus coeruleus neurons express MHC-I, and that this molecule is inducible in human stem cell derived dopamine (DA) neurons. Catecholamine murine cultured neurons are more responsive to induction of MHC-I by gamma-interferon than other neuronal populations. Neuronal MHC-I is also induced by factors released from microglia activated by neuromelanin or alpha-synuclein, or high cytosolic DA and/or oxidative stress. DA neurons internalize foreign ovalbumin and display antigen derived from this protein by MHC-I, which triggers DA neuronal death in the presence of appropriate cytotoxic T-cells. Thus, neuronal MHC-I can trigger antigenic response, and catecholamine neurons may be particularly susceptible to T cell-mediated cytotoxic attack.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ncomms4633en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024461/pdf/en
dash.licenseLAAen_US
dc.titleMHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degenerationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature communicationsen
dash.depositing.authorScherzer, Clemens R.en_US
dc.date.available2014-11-03T17:40:21Z
dc.identifier.doi10.1038/ncomms4633*
dash.authorsorderedfalse
dash.contributor.affiliatedScherzer, Clemens


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