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dc.contributor.authorSánchez Fernández, Ivánen_US
dc.contributor.authorLoddenkemper, Tobiasen_US
dc.date.accessioned2014-11-03T17:40:52Z
dc.date.issued2014en_US
dc.identifier.citationSánchez Fernández, Iván, and Tobias Loddenkemper. 2014. “Subunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brain.” BioMed Research International 2014 (1): 301950. doi:10.1155/2014/301950. http://dx.doi.org/10.1155/2014/301950.en
dc.identifier.issn2314-6133en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13347665
dc.description.abstractNeuronal activity is critical for synaptogenesis and the development of neuronal networks. In the immature brain excitation predominates over inhibition facilitating the development of normal brain circuits, but also rendering it more susceptible to seizures. In this paper, we review the evolution of the subunit composition of neurotransmitter receptors during development, how it promotes excitation in the immature brain, and how this subunit composition of neurotransmission receptors may be also present in the epileptic brain. During normal brain development, excitatory glutamate receptors peak in function and gamma-aminobutiric acid (GABA) receptors are mainly excitatory rather than inhibitory. A growing body of evidence from animal models of epilepsy and status epilepticus has demonstrated that the brain exposed to repeated seizures presents a subunit composition of neurotransmitter receptors that mirrors that of the immature brain and promotes further seizures and epileptogenesis. Studies performed in samples from the epileptic human brain have also found a subunit composition pattern of neurotransmitter receptors similar to the one found in the immature brain. These findings provide a solid rationale for tailoring antiepileptic treatments to the specific subunit composition of neurotransmitter receptors and they provide potential targets for the development of antiepileptogenic treatments.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2014/301950en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180637/pdf/en
dash.licenseLAAen_US
dc.titleSubunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brainen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBioMed Research Internationalen
dash.depositing.authorSánchez Fernández, Ivánen_US
dc.date.available2014-11-03T17:40:52Z
dc.identifier.doi10.1155/2014/301950*
dash.contributor.affiliatedSanchez Fernandez, Ivan
dash.contributor.affiliatedLoddenkemper, Tobias


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