Constitutive Neutrophil Apoptosis: Mechanisms and Regulation
| Title: | Constitutive Neutrophil Apoptosis: Mechanisms and Regulation |
| Author: |
Luo, Hongbo; Loison, Fabien
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Luo, Hongbo R., and Fabien Loison. 2008. “Constitutive Neutrophil Apoptosis: Mechanisms and Regulation.” American Journal of Hematology 83 (4) (April): 288–295. doi:10.1002/ajh.21078. http://dx.doi.org/10.1002/ajh.21078. |
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| Abstract: | Neutrophil constitutive death is a critical cellular process for modulating neutrophil number and function, and it plays an essential role in neutrophil homeostasis and the resolution of inflammation. Neutrophils die due to programmed cell death or apoptosis. In this article, we review recent studies on the mechanism of neutrophil apoptosis. The involvement of caspase, calpain, reactive oxygen species, cellular survival/death signaling pathways, mitochondria, and BCL-2 family member proteins are discussed. The fate of neutrophils can be influenced within the inflammatory microenvironment. We summarize the current understanding regarding the modulation of neutrophil apoptotic death by various extracellular stimuli such as proinflammatory cytokines, cell adhesion, phagocytosis, red blood cells, and platelets. The involvement of neutrophil apoptosis in infectious and inflammatory diseases is also addressed. |
| Published Version: | doi:10.1002/ajh.21078 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pubmed/17924549 |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:13348329 |
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