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dc.contributor.authorLuo, Hongbo
dc.contributor.authorLoison, Fabien
dc.date.accessioned2014-11-04T15:46:19Z
dc.date.issued2008
dc.identifier.citationLuo, Hongbo R., and Fabien Loison. 2008. “Constitutive Neutrophil Apoptosis: Mechanisms and Regulation.” American Journal of Hematology 83 (4) (April): 288–295. doi:10.1002/ajh.21078. http://dx.doi.org/10.1002/ajh.21078.en_US
dc.identifier.issn0361-8609en_US
dc.identifier.issn1096-8652en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13348329
dc.description.abstractNeutrophil constitutive death is a critical cellular process for modulating neutrophil number and function, and it plays an essential role in neutrophil homeostasis and the resolution of inflammation. Neutrophils die due to programmed cell death or apoptosis. In this article, we review recent studies on the mechanism of neutrophil apoptosis. The involvement of caspase, calpain, reactive oxygen species, cellular survival/death signaling pathways, mitochondria, and BCL-2 family member proteins are discussed. The fate of neutrophils can be influenced within the inflammatory microenvironment. We summarize the current understanding regarding the modulation of neutrophil apoptotic death by various extracellular stimuli such as proinflammatory cytokines, cell adhesion, phagocytosis, red blood cells, and platelets. The involvement of neutrophil apoptosis in infectious and inflammatory diseases is also addressed.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1002/ajh.21078en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/17924549en_US
dash.licenseMETA_ONLY
dc.titleConstitutive Neutrophil Apoptosis: Mechanisms and Regulationen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalAmerican Journal of Hematologyen_US
dash.depositing.authorLuo, Hongbo
dash.embargo.until10000-01-01
dc.identifier.doi10.1002/ajh.21078*
workflow.legacycommentsDeposit dark per Luoen_US
dash.contributor.affiliatedLoison, Fabien
dash.contributor.affiliatedLuo, Hongbo


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