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dc.contributor.authorLoffredo, Francesco
dc.contributor.authorSteinhauser, Matthew L.
dc.contributor.authorJay, Steven M.
dc.contributor.authorGannon, Joseph
dc.contributor.authorPancoast, James R.
dc.contributor.authorYalamanchi, Pratyusha
dc.contributor.authorSinha, Manisha
dc.contributor.authorDall’Osso, Claudia
dc.contributor.authorKhong, Danika Mei Po
dc.contributor.authorShadrach, J
dc.contributor.authorMiller, Christine
dc.contributor.authorSinger, Britta S.
dc.contributor.authorStewart, Alex
dc.contributor.authorPsychogios, Nikolaos
dc.contributor.authorGerszten, Robert Edgardo
dc.contributor.authorHartigan, Adam J.
dc.contributor.authorKim, Mi-Jeong
dc.contributor.authorSerwold, Thomas Francis
dc.contributor.authorWagers, Amy Jo
dc.contributor.authorLee, Richard Theodore
dc.date.accessioned2014-11-07T16:16:38Z
dc.date.issued2013
dc.identifier.citationLoffredo, Francesco S., Matthew L. Steinhauser, Steven M. Jay, Joseph Gannon, James R. Pancoast, Pratyusha Yalamanchi, Manisha Sinha, et al. 2013. “Growth Differentiation Factor 11 Is a Circulating Factor That Reverses Age-Related Cardiac Hypertrophy.” Cell 153 (4) (May): 828–839.en_US
dc.identifier.issn0092-8674en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13362665
dc.description.abstractThe most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation. After 4 weeks of exposure to the circulation of young mice, cardiac hypertrophy in old mice dramatically regressed, accompanied by reduced cardiomyocyte size and molecular remodeling. Reversal of age-related hypertrophy was not attributable to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor. Using modified aptamer-based proteomics, we identified the TGF-b superfamily member GDF11 as a circulating factor in young mice that declines with age. Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging.en_US
dc.description.sponsorshipStem Cell and Regenerative Biologyen_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.cell.2013.04.015en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/23663781en_US
dash.licenseMETA_ONLY
dc.titleGrowth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCellen_US
dash.depositing.authorWagers, Amy Jo
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/j.cell.2013.04.015*
workflow.legacycommentsdeposit darken_US
dash.authorsorderedfalse
dash.contributor.affiliatedSinha, Manisha
dash.contributor.affiliatedKhong, Danika
dash.contributor.affiliatedLoffredo, F
dash.contributor.affiliatedShadrach, Jennifer
dash.contributor.affiliatedMiller, Christine
dash.contributor.affiliatedSerwold, Thomas
dash.contributor.affiliatedSteinhauser, Matthew
dash.contributor.affiliatedLee, Richard
dash.contributor.affiliatedGerszten, Robert
dash.contributor.affiliatedWagers, Amy


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