Browsing SPH Theses and Dissertations by Keyword "Biology, Biostatistics"
Now showing items 1-8 of 8
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Development of Satellite-Based Emission Inventories and Indoor Exposure Prediction Models for PM2.5
(2016-09-28)Epidemiological studies have documented significant relationships between outdoor particle exposure and adverse health effects whilst indoor residential PM2.5 exposure is found to be the most influential on total PM2.5 ... -
DNA Methylation and Human Diseases: Applied and Methodological Studies
(2018-09-24)DNA methylation plays important roles in regulating gene expression and chromosome integrity via addition of methyl groups to cytosine residues. A growing number of human diseases have been found to be associated with ... -
Meta-Analysis of a Multi-Ethnic, Breast Cancer Case-Control Targeted Sequencing Study
(2015-05-01)Breast cancer, the most commonly diagnosed cancer in American women, is a heritable disease with nearly one hundred known genetic risk factors. Using next generation sequencing, we explored the contribution of genetics at ... -
Metabolomics in Obesity and Methods for Analyzing Multiple Phenotypes
(2015-04-23)In this dissertation, we first assess the associations between circulating metabolites and body mass index in two U.S. prospective cohorts. Then, we propose several methods to analyze multiple phenotypes in genetic association ... -
Summary Score-Based Confounding Control in Studies of New Drugs
(2017-09-21)Epidemiological studies of newly marketed drugs are often undertaken to assess questions of safety and effectiveness that did not arise during a drug’s pre-approval studies. However, unlike in randomized controlled trials, ... -
Toward a Causal Health Effect of Fine Particulate Air Pollution
(2018-04-09)Exposure to fine particulate matter (PM2.5) has been associated with many adverse health outcomes, including increased risk of mortality and hospital admissions. There have been criticisms challenging whether the reported ... -
Urinary Arsenic Methylation Species, Arsenic Methylation Efficiency during Pregnancy and Birth Outcomes
(2018-04-27)Arsenic exposure from drinking water has been associated with symptoms during pregnancy, as well as negative birth outcomes. The individual’s capability to methylate arsenic modifies the risk of arsenic-related health ... -
Use of Simulation to Aid Design of Clinical Trials During Infectious Disease Outbreaks
(2018-09-24)Clinical trials for infectious diseases conducted during epidemics are complicated by the unpredictable nature of outbreaks and dynamic effects arising from disease transmission. Mathematical models can be used to understand ...