Epidemiological studies have documented significant relationships between outdoor particle exposure and adverse health effects whilst indoor residential PM2.5 exposure is found to be the most influential on total PM2.5 ...

Exposure to fine particulate matter (PM2.5) has been associated with many adverse health outcomes, including increased risk of mortality and hospital admissions. There have been criticisms challenging whether the reported ...

Arsenic exposure from drinking water has been associated with symptoms during pregnancy, as well as negative birth outcomes. The individual’s capability to methylate arsenic modifies the risk of arsenic-related health ...

Clinical trials for infectious diseases conducted during epidemics are complicated by the unpredictable nature of outbreaks and dynamic effects arising from disease transmission. Mathematical models can be used to understand ...

Breast cancer, the most commonly diagnosed cancer in American women, is a heritable disease with nearly one hundred known genetic risk factors. Using next generation sequencing, we explored the contribution of genetics at ...

In this dissertation, we first assess the associations between circulating metabolites and body mass index in two U.S. prospective cohorts. Then, we propose several methods to analyze multiple phenotypes in genetic association ...

Epidemiological studies of newly marketed drugs are often undertaken to assess questions of safety and effectiveness that did not arise during a drug’s pre-approval studies. However, unlike in randomized controlled trials, ...

DNA methylation plays important roles in regulating gene expression and chromosome integrity via addition of methyl groups to cytosine residues. A growing number of human diseases have been found to be associated with ...