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Now showing items 11-20 of 106
Poverty, Energy Use, Air Pollution and Health in Ghana: A Spatial Analysis
(2015-05-01)
Some of the major themes that characterize the relationship between the environment and population health in the developing world today include poverty, household access to clean cooking fuel, air pollution, sanitation, ...
Psychosocial Factors, Lifestyle and Risk of Ovarian Cancer
(2015-04-23)
Current prevention recommendations for ovarian cancer are limited, and the underlying etiology is not fully elucidated. The associations of common modifiable factors, such as psychosocial and lifestyle factors, with ovarian ...
Meta-Analysis of a Multi-Ethnic, Breast Cancer Case-Control Targeted Sequencing Study
(2015-05-01)
Breast cancer, the most commonly diagnosed cancer in American women, is a heritable disease with nearly one hundred known genetic risk factors. Using next generation sequencing, we explored the contribution of genetics at ...
Mitochondrial DNA Copy Number, Lifestyle and Cancer Risk
(2015-05-01)
Mitochondria are membrane-bound organelles found in the cytoplasm of almost all eukaryotic cells. Their main functions include energy metabolism, free radical production, calcium homeostasis and apoptosis. Located closely ...
Mediation Analysis in Understanding Mechanism of Alzheimer’s Disease Risk
(2015-04-27)
Although studies often show reduced risk of dementia with late-life cognitive activity, concerns about residual confounding and reverse causation cast doubt on these findings. In Chapter 1 of this dissertation, we review ...
Dietary and Reproductive Risk Factors for Breast Cancer in the Nurses' Health Studies
(2015-04-27)
Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among US women. Several hormonal, anthropometric, lifestyle, and genetic factors are known to be associated with breast ...
Mechanisms and Risk Factors of Cognitive Aging
(2015-04-21)
This dissertation explores the role of biologic factors and a novel method of measuring cognitive function in investigating mechanisms and risk factors of cognitive aging. With a rapidly increasing aging population, the ...
Nutrient Validation In Women's Lifestyle Validation Study
(2015-04-27)
Nutritional factors have been intensively studied as important determinants of many diseases. Food frequency questionnaires (FFQ), dietary records, 24-hour dietary recalls, nutrient biomarkers are important dietary assessment ...
Metabolomics in Obesity and Methods for Analyzing Multiple Phenotypes
(2015-04-23)
In this dissertation, we first assess the associations between circulating metabolites and body mass index in two U.S. prospective cohorts. Then, we propose several methods to analyze multiple phenotypes in genetic association ...
The Effect of Head Injury on Neurologic and Cognitive Health Throughout the Life Course
(2015-05-01)
Recent studies touting the potential long term negative effects of traumatic brain injuries have pushed these injuries in the forefront of public health concern. There is particular concern of whether or not there is a ...