Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations
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Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations
| Title: | Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations |
| Author: |
Desai, Michael Manish; Walczak, Aleksandra M.; Fisher, Daniel S.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Desai, Michael M., Aleksandra M. Walczak, and Daniel S. Fisher. 2013. Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations. Genetics 193, no. 2: 565–585. |
| Full Text & Related Files: |
1208.3381v1.pdf (1.931Mb; PDF) 
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| Abstract: | Positive selection distorts the structure of genealogies and hence alters patterns of genetic variation within a population. Most analyses of these distortions focus on the signatures of hitchhiking due to hard or soft selective sweeps at a single genetic locus. However, in linked regions of rapidly adapting genomes, multiple beneficial mutations at different loci can segregate simultaneously within the population, an effect known as clonal interference. This leads to a subtle interplay between hitchhiking and interference effects, which leads to a unique signature of rapid adaptation on genetic variation both at the selected sites and at linked neutral loci. Here, we introduce an effective coalescent theory (a “fitness-class coalescent”) that describes how positive selection at many perfectly linked sites alters the structure of genealogies. We use this theory to calculate several simple statistics describing genetic variation within a rapidly adapting population and to implement efficient backward-time coalescent simulations, which can be used to predict how clonal interference alters the expected patterns of molecular evolution. |
| Published Version: | doi:10.1534/genetics.112.147157 |
| Other Sources: | http://arxiv.org/pdf/1208.3381v1.pdf |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:13403351 |
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