Introduction to Focus Issue: Genetic Interactions
MetadataShow full item record
CitationSegrè, Daniel, and Christopher J. Marx. 2010. “Introduction to Focus Issue: Genetic Interactions.” Chaos: An Interdisciplinary Journal of Nonlinear Science 20 (2): 026101. doi:10.1063/1.3456057.
AbstractThe perturbation of a gene in an organism’s genome often causes changes in the organism’s observable properties or phenotypes. It is not obvious a priori whether the simultaneous perturbation of two genes produces a phenotypic change that is easily predictable from the changes caused by individual perturbations. In fact, this is often not the case: the nonlinearity and interdependence between genetic variants in determining phenotypes, also known as epistasis, is a prevalent phenomenon in biological systems. This focus issue presents recent developments in the study of epistasis and genetic interactions, emphasizing the broad implications of this phenomenon in evolutionary biology, functional genomics, and human diseases.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13411987
- FAS Scholarly Articles