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dc.contributor.authorWeng, Pei-Hsuanen_US
dc.contributor.authorHuang, Yi-Lingen_US
dc.contributor.authorPage, John H.en_US
dc.contributor.authorChen, Jen-Hauen_US
dc.contributor.authorXu, Jianfengen_US
dc.contributor.authorKoutros, Stellaen_US
dc.contributor.authorBerndt, Sonjaen_US
dc.contributor.authorChanock, Stephenen_US
dc.contributor.authorYeager, Meredithen_US
dc.contributor.authorWitte, John S.en_US
dc.contributor.authorEeles, Rosalind A.en_US
dc.contributor.authorEaston, Douglas F.en_US
dc.contributor.authorNeal, David E.en_US
dc.contributor.authorDonovan, Jennyen_US
dc.contributor.authorHamdy, Freddie C.en_US
dc.contributor.authorMuir, Kenneth R.en_US
dc.contributor.authorGiles, Grahamen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorSmith, Jeffrey R.en_US
dc.contributor.authorBalistreri, Carmela R.en_US
dc.contributor.authorShui, Irene M.en_US
dc.contributor.authorChen, Yen-Chingen_US
dc.date.accessioned2014-12-02T21:27:46Z
dc.date.issued2014en_US
dc.identifier.citationWeng, P., Y. Huang, J. H. Page, J. Chen, J. Xu, S. Koutros, S. Berndt, et al. 2014. “Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis.” PLoS ONE 9 (10): e110569. doi:10.1371/journal.pone.0110569. http://dx.doi.org/10.1371/journal.pone.0110569.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13454684
dc.description.abstractBackground: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews. Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls. Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity. Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0110569en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215920/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectEvolutionary Biologyen
dc.subjectPopulation Geneticsen
dc.subjectGenetic Polymorphismen
dc.subjectGeneticsen
dc.subjectCancer Geneticsen
dc.subjectPhysical Sciencesen
dc.subjectMathematicsen
dc.subjectStatistics (Mathematics)en
dc.subjectStatistical Methodsen
dc.subjectMeta-Analysisen
dc.subjectSystematic Reviewsen
dc.titlePolymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorShui, Irene M.en_US
dc.date.available2014-12-02T21:27:46Z
dc.identifier.doi10.1371/journal.pone.0110569*
dash.authorsorderedfalse
dash.contributor.affiliatedShui, Irene


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