Synthesis and patterning of tunable multiscale materials with engineered cells

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Synthesis and patterning of tunable multiscale materials with engineered cells

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Title: Synthesis and patterning of tunable multiscale materials with engineered cells
Author: Chen, Allen Y.; Deng, Zhengtao; Billings, Amanda N.; Seker, Urartu O.S.; Lu, Michelle Y.; Citorik, Robert J.; Zakeri, Bijan; Lu, Timothy K.

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Citation: Chen, Allen Y., Zhengtao Deng, Amanda N. Billings, Urartu O.S. Seker, Michelle Y. Lu, Robert J. Citorik, Bijan Zakeri, and Timothy K. Lu. 2014. “Synthesis and patterning of tunable multiscale materials with engineered cells.” Nature materials 13 (5): 515-523. doi:10.1038/nmat3912. http://dx.doi.org/10.1038/nmat3912.
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Abstract: Many natural biological systems - such as biofilms, shells and skeletal tissues - are able to assemble multifunctional and environmentally responsive multiscale assemblies of living and non-living components. Here, by using inducible genetic circuits and cellular communication circuits to regulate Escherichia coli curli amyloid production, we show that E. coli cells can organize self-assembling amyloid fibrils across multiple length scales, producing amyloid-based materials that are either externally controllable or undergo autonomous patterning. We also interfaced curli fibrils with inorganic materials, such as gold nanoparticles (AuNPs) and quantum dots (QDs), and used these capabilities to create an environmentally responsive biofilm-based electrical switch, produce gold nanowires and nanorods, co-localize AuNPs with CdTe/CdS QDs to modulate QD fluorescence lifetimes, and nucleate the formation of fluorescent ZnS QDs. This work lays a foundation for synthesizing, patterning, and controlling functional composite materials with engineered cells.
Published Version: doi:10.1038/nmat3912
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063449/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454699
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