Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study
View/ Open
Author
Davies, Benjamin M
Rikabi, Sarah
French, Anna
Pinedo-Villanueva, Rafael
Morrey, Mark E
Wartolowska, Karolina
Judge, Andrew
MacLaren, Robert E
Mathur, Anthony
Williams, David J
Wall, Ivan
Birchall, Martin
Reeve, Brock
Atala, Anthony
Barker, Richard W
Cui, Zhanfeng
Furniss, Dominic
Bure, Kim
Snyder, Evan Y
Price, Andrew
Carr, Andrew
Brindley, David A
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1177/2041731414551764Metadata
Show full item recordCitation
Davies, B. M., S. Rikabi, A. French, R. Pinedo-Villanueva, M. E. Morrey, K. Wartolowska, A. Judge, et al. 2014. “Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.” Journal of Tissue Engineering 5 (1): 2041731414551764. doi:10.1177/2041731414551764. http://dx.doi.org/10.1177/2041731414551764.Abstract
There has been a large increase in basic science activity in cell therapy and a growing portfolio of cell therapy trials. However, the number of industry products available for widespread clinical use does not match this magnitude of activity. We hypothesize that the paucity of engagement with the clinical community is a key contributor to the lack of commercially successful cell therapy products. To investigate this, we launched a pilot study to survey clinicians from five specialities and to determine what they believe to be the most significant barriers to cellular therapy clinical development and adoption. Our study shows that the main concerns among this group are cost-effectiveness, efficacy, reimbursement, and regulation. Addressing these concerns can best be achieved by ensuring that future clinical trials are conducted to adequately answer the questions of both regulators and the broader clinical community.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221931/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454714
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)