Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)

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Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)

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Title: Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)
Author: Xie, Zhihui; Chan, Eunice; Yin, Yuzhi; Ghosh, Chandra C.; Wisch, Laura; Nelson, Celeste; Young, Michael; Parikh, Samir M.; Druey, Kirk M.

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Citation: Xie, Zhihui, Eunice Chan, Yuzhi Yin, Chandra C. Ghosh, Laura Wisch, Celeste Nelson, Michael Young, Samir M. Parikh, and Kirk M. Druey. 2014. “Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease).” Journal of clinical & cellular immunology 5 (1): 1000213. doi:10.4172/2155-9899.1000213. http://dx.doi.org/10.4172/2155-9899.1000213.
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Abstract: Objectives: The Systemic Capillary Leak Syndrome (SCLS) is a rare and potentially fatal disorder resembling systemic anaphylaxis that is characterized by transient episodes of hypotensive shock and peripheral edema. The pathogenesis of SCLS is unknown, and triggers for attacks are apparent only in a minority of patients. We introduce a clinical algorithm for the diagnosis of SCLS, and we investigated potential serum biomarkers of acute SCLS episodes. Methods: We analyzed serum cytokines in a cohort of 35 patients with an established diagnosis of SCLS and characterized the effects of SCLS sera on endothelial cell function. We investigated the cellular source(s) of CXCL10, a chemokine that was significantly elevated in both basal and acute SCLS sera, by flow cytometry. Results: Several cytokines were elevated in acute SCLS sera compared to baseline or sera from healthy controls, including CXCL10, CCL2, IL-1β, IL-6, IL-8, IL-12 and TNFα. The majority of acute sera failed to activate endothelial cells as assessed by surface adhesion marker expression. Monocytes appear to be the major source of serum CXCL10, and the percentage of CXLC10+ monocytes in response to IFNγ stimulation was increased in SCLS subjects compared to controls. Conclusions: The presence of proinflammatory cytokines in acute SCLS sera suggests that inflammation or infection may have a role in triggering episodes. The enhanced capacity of monocytes from SCLS patients to produce CXCL10 suggests a new therapeutic avenue for SCLS.
Published Version: doi:10.4172/2155-9899.1000213
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232957/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454768
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