Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes

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Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes

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Title: Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes
Author: Sieber, Jonas; Jehle, Andreas Werner

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Citation: Sieber, Jonas, and Andreas Werner Jehle. 2014. “Free Fatty Acids and Their Metabolism Affect Function and Survival of Podocytes.” Frontiers in Endocrinology 5 (1): 186. doi:10.3389/fendo.2014.00186. http://dx.doi.org/10.3389/fendo.2014.00186.
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Abstract: Podocyte injury and loss critically contribute to the pathogenesis of proteinuric kidney diseases including diabetic nephropathy. Deregulated lipid metabolism with disturbed free fatty acid (FFA) metabolism is a characteristic of metabolically unhealthy obesity and type 2 diabetes and likely contributes to end-stage kidney disease irrespective of the underlying kidney disease. In the current review, we summarize recent findings related to FFAs and altered renal FFA metabolism with a special focus on podocytes. We will outline the opposing effects of saturated and monounsaturated FFAs and a particular emphasis will be given to the underlying molecular mechanisms involving insulin resistance and endoplasmic reticulum homeostasis. Finally, recent data suggesting a critical role of renal FFA metabolism to adapt to an altered lipid environment will be discussed.
Published Version: doi:10.3389/fendo.2014.00186
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209866/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13454833
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