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dc.contributor.authorRojas-Mirquez, Johanna Carolinaen_US
dc.contributor.authorRodriguez-Zuñiga, Milton Jose Maxen_US
dc.contributor.authorBonilla-Escobar, Francisco Javieren_US
dc.contributor.authorGarcia-Perdomo, Herney Andresen_US
dc.contributor.authorPetkov, Mikeen_US
dc.contributor.authorBecerra, Linoen_US
dc.contributor.authorBorsook, Daviden_US
dc.contributor.authorLinnman, Clasen_US
dc.date.accessioned2014-12-02T21:29:19Z
dc.date.issued2014en_US
dc.identifier.citationRojas-Mirquez, Johanna Carolina, Milton Jose Max Rodriguez-Zuñiga, Francisco Javier Bonilla-Escobar, Herney Andres Garcia-Perdomo, Mike Petkov, Lino Becerra, David Borsook, and Clas Linnman. 2014. “Nocebo Effect in Randomized Clinical Trials of Antidepressants in Children and Adolescents: Systematic Review and Meta-Analysis.” Frontiers in Behavioral Neuroscience 8 (1): 375. doi:10.3389/fnbeh.2014.00375. http://dx.doi.org/10.3389/fnbeh.2014.00375.en
dc.identifier.issn1662-5153en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13454854
dc.description.abstractObjective:: To compare the incidence of adverse events between active and placebo arms of randomized clinical trials in depressive children and adolescents (C&A) with antidepressant treatments, in order to look for similarities in both groups that allow to establish a possible nocebo effect. Methods:: Systematic search strategy (January 1974–March 2013) in electronic databases, conference abstracts, and reference list of systematic reviews and included studies to identify parallel randomized placebo-controlled trials of antidepressants in C&A (<19 years) with major depressive disorder, and one or more interventions of any orally administered antidepressant. The pooled adverse events were calculated based on a fixed-effect model and statistical analysis involved the risk ratio (RR) of adverse events, with 95% confidence intervals (95% CI). Results:: Sixteen studies were included in the review, of which seven studies with a sample of 1911 patients had data to include in the meta-analysis. There was similar risk for the incidence of adverse events between non-active and active group (global RR 1.04, 95% CI: 0.97–1.11). Conclusion:: Depressive C&A allocated to placebo or active group had similar risk to develop adverse events. These similarities in both groups are attributed to the nocebo effect. It is of note that defining “nocebo” effects is challenging in clinical populations because adverse effects may be attributed to the intervention or may be manifestation of the disease itself. The inclusion of a no-treatment arm may be warranted. Nocebo effects are likely when adverse events of placebo mimic the adverse events of active treatment, as was the case here.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fnbeh.2014.00375en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217505/pdf/en
dash.licenseLAAen_US
dc.subjectnoceboen
dc.subjectchildrenen
dc.subjectadolescentsen
dc.subjectantidepressantsen
dc.subjectmeta-analysisen
dc.titleNocebo Effect in Randomized Clinical Trials of Antidepressants in Children and Adolescents: Systematic Review and Meta-Analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Behavioral Neuroscienceen
dash.depositing.authorBecerra, Linoen_US
dc.date.available2014-12-02T21:29:19Z
dc.identifier.doi10.3389/fnbeh.2014.00375*
dash.contributor.affiliatedLinnman, Nils
dash.contributor.affiliatedBecerra, Lino
dash.contributor.affiliatedBorsook, David


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