B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS
O’Donovan, Kevin J.
Han, Seung Baek
Wong, Jamie K.
Zhong, JianNote: Order does not necessarily reflect citation order of authors.
MetadataShow full item record
CitationO’Donovan, K. J., K. Ma, H. Guo, C. Wang, F. Sun, S. B. Han, H. Kim, et al. 2014. “B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.” The Journal of Experimental Medicine 211 (5): 801-814. doi:10.1084/jem.20131780. http://dx.doi.org/10.1084/jem.20131780.
AbstractActivation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo in the absence of upstream neurotrophin signaling. We further show that activated B-RAF signaling enables robust regenerative growth of sensory axons into the spinal cord after a dorsal root crush as well as substantial axon regrowth in the crush-lesioned optic nerve. Finally, the combination of B-RAF gain-of-function and PTEN loss-of-function promotes optic nerve axon extension beyond what would be predicted for a simple additive effect. We conclude that cell-intrinsic RAF signaling is a crucial pathway promoting developmental and regenerative axon growth in the peripheral and central nervous systems.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13454857
- HMS Scholarly Articles 
Contact administrator regarding this item (to report mistakes or request changes)