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dc.contributor.authorO’Donovan, Kevin J.en_US
dc.contributor.authorMa, Kaijieen_US
dc.contributor.authorGuo, Hengchangen_US
dc.contributor.authorWang, Chenen_US
dc.contributor.authorSun, Fangen_US
dc.contributor.authorHan, Seung Baeken_US
dc.contributor.authorKim, Hyukminen_US
dc.contributor.authorWong, Jamie K.en_US
dc.contributor.authorCharron, Jeanen_US
dc.contributor.authorZou, Hongyanen_US
dc.contributor.authorSon, Young-Jinen_US
dc.contributor.authorHe, Zhigangen_US
dc.contributor.authorZhong, Jianen_US
dc.date.accessioned2014-12-02T21:29:21Z
dc.date.issued2014en_US
dc.identifier.citationO’Donovan, K. J., K. Ma, H. Guo, C. Wang, F. Sun, S. B. Han, H. Kim, et al. 2014. “B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.” The Journal of Experimental Medicine 211 (5): 801-814. doi:10.1084/jem.20131780. http://dx.doi.org/10.1084/jem.20131780.en
dc.identifier.issn0022-1007en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13454857
dc.description.abstractActivation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo in the absence of upstream neurotrophin signaling. We further show that activated B-RAF signaling enables robust regenerative growth of sensory axons into the spinal cord after a dorsal root crush as well as substantial axon regrowth in the crush-lesioned optic nerve. Finally, the combination of B-RAF gain-of-function and PTEN loss-of-function promotes optic nerve axon extension beyond what would be predicted for a simple additive effect. We conclude that cell-intrinsic RAF signaling is a crucial pathway promoting developmental and regenerative axon growth in the peripheral and central nervous systems.en
dc.language.isoen_USen
dc.publisherThe Rockefeller University Pressen
dc.relation.isversionofdoi:10.1084/jem.20131780en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010899/pdf/en
dash.licenseLAAen_US
dc.titleB-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNSen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalThe Journal of Experimental Medicineen
dash.depositing.authorSun, Fangen_US
dc.date.available2014-12-02T21:29:21Z
dc.identifier.doi10.1084/jem.20131780*
dash.authorsorderedfalse
dash.contributor.affiliatedSun, Fang
dash.contributor.affiliatedHe, Zhigang


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