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dc.contributor.authorDucharme, Anique
dc.contributor.authorFrantz, Stefan
dc.contributor.authorAikawa, Masanori
dc.contributor.authorRabkin, Elena
dc.contributor.authorLindsey, Merry
dc.contributor.authorRohde, Luis E.
dc.contributor.authorSchoen, Frederick Jack
dc.contributor.authorKelly, Ralph A.
dc.contributor.authorWerb, Zena
dc.contributor.authorLibby, Peter
dc.contributor.authorLee, Richard Theodore
dc.date.accessioned2014-12-12T21:21:39Z
dc.date.issued2000
dc.identifier.citationDucharme, Anique, Stefan Frantz, Masanori Aikawa, Elena Rabkin, Merry Lindsey, Luis E. Rohde, Frederick J. Schoen, et al. 2000. “Targeted Deletion of Matrix Metalloproteinase-9 Attenuates Left Ventricular Enlargement and Collagen Accumulation after Experimental Myocardial Infarction.” J. Clin. Invest. 106 (1) (July 1): 55–62. doi:10.1172/jci8768.en_US
dc.identifier.issn0021-9738en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13506942
dc.description.abstractMatrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental MI than do sibling wild-type (WT) mice. Animals that survived ligation of the left coronary artery underwent echocardiographic studies after MI; all analyses were performed without knowledge of mouse genotype. By day 8, MMP9 knockout (KO) mice had significantly smaller increases in end-diastolic and end-systolic ventricular dimensions at both midpapillary and apical levels, compared with infarcted WT mice; these differences persisted at 15 days after MI. MMP-9 KO mice had less collagen accumulation in the infarcted area than did WT mice, and they showed enhanced expression of MMP-2, MMP-13, and TIMP-1 and a reduced number of macrophages. We conclude that targeted deletion of the MMP9 gene attenuates LV dilation after experimental MI in mice. The decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Clinical Investigationen_US
dc.relation.isversionofdoi:10.1172/JCI8768en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/10880048en_US
dash.licenseLAA
dc.titleTargeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarctionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Clinical Investigationen_US
dash.depositing.authorLibby, Peter
dc.date.available2014-12-12T21:21:39Z
dc.identifier.doi10.1172/JCI8768*
dash.authorsorderedfalse
dash.contributor.affiliatedSchoen, Frederick
dash.contributor.affiliatedAikawa, Masanori
dash.contributor.affiliatedLee, Richard
dash.contributor.affiliatedLibby, Peter


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