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dc.contributor.authorSeim, Ingeen_US
dc.contributor.authorMa, Simingen_US
dc.contributor.authorZhou, Xumingen_US
dc.contributor.authorGerashchenko, Maxim V.en_US
dc.contributor.authorLee, Sang-Gooen_US
dc.contributor.authorSuydam, Roberten_US
dc.contributor.authorGeorge, John C.en_US
dc.contributor.authorBickham, John W.en_US
dc.contributor.authorGladyshev, Vadim N.en_US
dc.date.accessioned2015-01-05T18:26:04Z
dc.date.issued2014en_US
dc.identifier.citationSeim, Inge, Siming Ma, Xuming Zhou, Maxim V. Gerashchenko, Sang-Goo Lee, Robert Suydam, John C. George, John W. Bickham, and Vadim N. Gladyshev. 2014. “The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.” Aging (Albany NY) 6 (10): 879-899.en
dc.identifier.issn1945-4589en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13581028
dc.description.abstractMammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in excess of two hundred years. It is also one of the two largest animals and the most cold-adapted baleen whale species. Here, we report the first genome-wide gene expression analyses of the bowhead whale, based on the de novo assembly of its transcriptome. Bowhead whale or cetacean-specific changes in gene expression were identified in the liver, kidney and heart, and complemented with analyses of positively selected genes. Changes associated with altered insulin signaling and other gene expression patterns could help explain the remarkable longevity of bowhead whales as well as their adaptation to a lipid-rich diet. The data also reveal parallels in candidate longevity adaptations of the bowhead whale, naked mole rat and Brandt's bat. The bowhead whale transcriptome is a valuable resource for the study of this remarkable animal, including the evolution of longevity and its important correlates such as resistance to cancer and other diseases.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247388/pdf/en
dash.licenseLAAen_US
dc.subjectbowhead whaleen
dc.subjecttranscriptomeen
dc.subjectinsulin/IGF1-axisen
dc.subjectagingen
dc.subjectevolutionen
dc.titleThe transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammalen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAging (Albany NY)en
dash.depositing.authorSeim, Ingeen_US
dc.date.available2015-01-05T18:26:04Z
dash.contributor.affiliatedSeim, Inge
dash.contributor.affiliatedMa, Siming
dash.contributor.affiliatedLee, Sang-Goo
dash.contributor.affiliatedZhou, Xuming
dash.contributor.affiliatedGerashchenko, Maxim
dash.contributor.affiliatedGladyshev, Vadim
dc.identifier.orcid0000-0002-1810-8357


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