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dc.contributor.authorKaida, Angelaen_US
dc.contributor.authorMatthews, Lynn T.en_US
dc.contributor.authorAshaba, Scholasticen_US
dc.contributor.authorTsai, Alexander C.en_US
dc.contributor.authorKanters, Steveen_US
dc.contributor.authorRobak, Magdalenaen_US
dc.contributor.authorPsaros, Christinaen_US
dc.contributor.authorKabakyenga, Jeromeen_US
dc.contributor.authorBoum, Yapen_US
dc.contributor.authorHaberer, Jessica E.en_US
dc.contributor.authorMartin, Jeffrey N.en_US
dc.contributor.authorHunt, Peter W.en_US
dc.contributor.authorBangsberg, David R.en_US
dc.date.accessioned2015-01-05T18:26:21Z
dc.date.issued2014en_US
dc.identifier.citationKaida, A., L. T. Matthews, S. Ashaba, A. C. Tsai, S. Kanters, M. Robak, C. Psaros, et al. 2014. “Depression During Pregnancy and the Postpartum Among HIV-Infected Women on Antiretroviral Therapy in Uganda.” Journal of Acquired Immune Deficiency Syndromes (1999) 67 (Suppl 4): S179-S187. doi:10.1097/QAI.0000000000000370. http://dx.doi.org/10.1097/QAI.0000000000000370.en
dc.identifier.issn1525-4135en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:13581034
dc.description.abstractBackground: Among HIV-infected women, perinatal depression compromises clinical, maternal, and child health outcomes. Antiretroviral therapy (ART) is associated with lower depression symptom severity but the uniformity of effect through pregnancy and postpartum periods is unknown. Methods: We analyzed prospective data from 447 HIV-infected women (18–49 years) initiating ART in rural Uganda (2005–2012). Participants completed blood work and comprehensive questionnaires quarterly. Pregnancy status was assessed by self-report. Analysis time periods were defined as currently pregnant, postpartum (0–12 months post-pregnancy outcome), or non–pregnancy-related. Depression symptom severity was measured using a modified Hopkins Symptom Checklist 15, with scores ranging from 1 to 4. Probable depression was defined as >1.75. Linear regression with generalized estimating equations was used to compare mean depression scores over the 3 periods. Results: At enrollment, median age was 32 years (interquartile range: 27–37), median CD4 count was 160 cells per cubic millimeter (interquartile range: 95–245), and mean depression score was 1.75 (s = 0.58) (39% with probable depression). Over 4.1 median years of follow-up, 104 women experienced 151 pregnancies. Mean depression scores did not differ across the time periods (P = 0.75). Multivariable models yielded similar findings. Increasing time on ART, viral suppression, better physical health, and “never married” were independently associated with lower mean depression scores. Findings were consistent when assessing probable depression. Conclusions: Although the lack of association between depression and perinatal periods is reassuring, high depression prevalence at treatment initiation and continued incidence across pregnancy and non–pregnancy-related periods of follow-up highlight the critical need for mental health services for HIV-infected women to optimize both maternal and perinatal health.en
dc.language.isoen_USen
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen
dc.relation.isversionofdoi:10.1097/QAI.0000000000000370en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251908/pdf/en
dash.licenseLAAen_US
dc.subjectdepressionen
dc.subjectpregnancyen
dc.subjectpostpartumen
dc.subjectperinatalen
dc.subjectHIV infectionen
dc.subjectantiretroviral therapyen
dc.subjectmental healthen
dc.subjectmaternal healthen
dc.subjectUgandaen
dc.titleDepression During Pregnancy and the Postpartum Among HIV-Infected Women on Antiretroviral Therapy in Ugandaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of Acquired Immune Deficiency Syndromes (1999)en
dash.depositing.authorMatthews, Lynn T.en_US
dc.date.available2015-01-05T18:26:21Z
dc.identifier.doi10.1097/QAI.0000000000000370*
dash.authorsorderedfalse
dash.contributor.affiliatedRobak, Magdalena
dash.contributor.affiliatedPsaros, Christina
dash.contributor.affiliatedTsai, Alexander
dash.contributor.affiliatedMatthews, Lynn
dash.contributor.affiliatedHaberer, Jessica
dash.contributor.affiliatedBangsberg, David R.


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