Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study

View/ Open
Author
Crous-Bou, Marta
Julin, Bettina
Du, Mengmeng
Published Version
https://doi.org/10.1136/bmj.g6674Metadata
Show full item recordCitation
Crous-Bou, Marta, Teresa T Fung, Jennifer Prescott, Bettina Julin, Mengmeng Du, Qi Sun, Kathryn M Rexrode, Frank B Hu, and Immaculata De Vivo. 2014. “Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study.” BMJ : British Medical Journal 349 (1): g6674. doi:10.1136/bmj.g6674. http://dx.doi.org/10.1136/bmj.g6674.Abstract
Objective: To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging. Design: Population based cohort study. Setting: Nurses’ Health Study, an ongoing prospective cohort study of 121 700 nurses enrolled in 1976; in 1989-90 a subset of 32 825 women provided blood samples. Participants: 4676 disease-free women from nested case-control studies within the Nurses’ Health Study with telomere length measured who also completed food frequency questionnaires. Main outcome measure Association between relative telomere lengths in peripheral blood leukocytes measured by quantitative real time polymerase chain reaction and Alternate Mediterranean Diet score calculated from self reported dietary data. Results: Greater adherence to the Mediterranean diet was associated with longer telomeres after adjustment for potential confounders. Least squares mean telomere length z scores were −0.038 (SE 0.035) for the lowest Mediterranean diet score groups and 0.072 (0.030) for the highest group (P for trend=0.004). Conclusion: In this large study, greater adherence to the Mediterranean diet was associated with longer telomeres. These results further support the benefits of adherence to the Mediterranean diet for promoting health and longevity.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252824/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581036
Collections
- HMS Scholarly Articles [17714]
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)