Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

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Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

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Title: Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
Author: Weber, Georg F.; Chousterman, Benjamin G.; Hilgendorf, Ingo; Robbins, Clinton S.; Theurl, Igor; Gerhardt, Louisa M.S.; Iwamoto, Yoshiko; Quach, Tam D.; Ali, Muhammad; Chen, John W.; Rothstein, Thomas L.; Nahrendorf, Matthias; Weissleder, Ralph; Swirski, Filip K.

Note: Order does not necessarily reflect citation order of authors.

Citation: Weber, G. F., B. G. Chousterman, I. Hilgendorf, C. S. Robbins, I. Theurl, L. M. Gerhardt, Y. Iwamoto, et al. 2014. “Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.” The Journal of Experimental Medicine 211 (6): 1243-1256. doi:10.1084/jem.20131471. http://dx.doi.org/10.1084/jem.20131471.
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Abstract: Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. The strategic location of these cells, coupled with the capacity to produce GM-CSF–dependent IgM, ensures effective early frontline defense against bacteria invading the lungs. The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity.
Published Version: doi:10.1084/jem.20131471
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042649/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581145
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